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kek1 kekkon 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34688, updated on 9-Dec-2024

Summary

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Official Symbol
kek1provided by FlyBase
Official Full Name
kekkon 1provided by FlyBase
Primary source
FLYBASE:FBgn0015399
Locus tag
Dmel_CG12283
See related
AllianceGenome:FB:FBgn0015399
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:GM02380; CG12283; CT18186; Dmel\CG12283; Dmkek1; GM02380; kek; Kek; kek-1; Kek-1; Kek1; KEK1; kekon; l(2)01433; n(2)k07332; NB1; SD01674; uns
Summary
Enables epidermal growth factor receptor binding activity and signaling receptor inhibitor activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and oogenesis. Located in apical plasma membrane. Is expressed in several structures, including cuboidal/columnar epithelium; follicle cell; imaginal disc; larval midline neurons; and peripheral nervous system. Orthologous to human LRRC24 (leucine rich repeat containing 24). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See kek1 in Genome Data Viewer
Location:
34A1-34A1; 2-47 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12817000..12822787, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12817000..12822787, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long noncoding RNA: testis-specific 9 Neighboring gene long non-coding RNA:CR43818 Neighboring gene long non-coding RNA:CR44970 Neighboring gene long non-coding RNA:CR44971

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Slit branches out: a secreted protein mediates both attractive and repulsive axon guidance. Zinn K, et al. Cell, 1999 Apr 2. PMID 10199395
  2. The Drosophila kekkon genes: novel members of both the leucine-rich repeat and immunoglobulin superfamilies expressed in the CNS. Musacchio M, et al. Dev Biol, 1996 Aug 25. PMID 8812109
  3. Quantitative analysis of the GAL4/UAS system in Drosophila oogenesis. Goentoro LA, et al. Genesis, 2006 Feb. PMID 16425298
  4. Control of bract formation in Drosophila: poxn, kek1, and the EGF-R pathway. Layalle S, et al. Genesis, 2004 Aug. PMID 15286997
  5. Knockouts of Kekkon1 define sequence elements essential for Drosophila epidermal growth factor receptor inhibition. Alvarado D, et al. Genetics, 2004 Jan. PMID 15020418, Free PMC Article

See all (136) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kek1 inhibits EGFR activity during eye development
    Title: Knockouts of Kekkon1 define sequence elements essential for Drosophila epidermal growth factor receptor inhibition.
  2. kek1 can suppress bract formation and can interfere with other steps of sensory development, including Sensory Mother Cell determination and shaft differentiation.
    Title: Control of bract formation in Drosophila: poxn, kek1, and the EGF-R pathway.
  3. the leucine-rich repeats of Kek1 in conjunction with its juxta/transmembrane region direct association and inhibition of the Drosophila EGFR through interactions with receptor domain V
    Title: Bipartite inhibition of Drosophila epidermal growth factor receptor by the extracellular and transmembrane domains of Kekkon1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
kekkon 1
Names
CG12283-PB
CG12283-PC
Kekkon1
Kekon-1
kek1-PB
kek1-PC
kekkon
kekkon-1
kekkonI
unstrung

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12817000..12822787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078835.3 → NP_523559.3  kekkon 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523559.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    L7XBB4, P91643, Q9VK54
    Conserved Domains (6) summary
    cd00096
    Location:346 → 426
    Ig; Immunoglobulin domain
    smart00082
    Location:277 → 327
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:338 → 429
    IG_like; Immunoglobulin like
    cd00116
    Location:119 → 277
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:103 → 122
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:148 → 207
    LRR_8; Leucine rich repeat

  2. NM_001316391.1 → NP_001303320.1  kekkon 1, isoform C [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    L7XBB4, P91643, Q9VK54
    Conserved Domains (6) summary
    cd00096
    Location:346 → 426
    Ig; Immunoglobulin domain
    smart00082
    Location:277 → 327
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:338 → 429
    IG_like; Immunoglobulin like
    cd00116
    Location:119 → 277
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:103 → 122
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:148 → 207
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91643 P91643
Q2XY32 Q2XY32
Q8T3J2 Q8T3J2
Q9VK54 Q9VK54

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