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Sirt1 - Sirtuin 1

Enables NAD-dependent histone deacetylase activity and transcription coactivator binding activity. Involved in several processes, including behavioral response to ethanol; determination of adult lifespan; and regulation of gene expression. Located in cytoplasm and nucleoplasm. Is expressed in several structures, including embryonic/larval garland cell; embryonic/larval salivary gland; germ band; larval central nervous system; and ventral nerve cord. Used to study alcohol use disorder and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to Sirt1

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Species Gene Architecture aa