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Pect Phosphoethanolamine cytidylyltransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34716, updated on 4-Jan-2025

Summary

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Official Symbol
Pectprovided by FlyBase
Official Full Name
Phosphoethanolamine cytidylyltransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0032482
Locus tag
Dmel_CG5547
See related
AllianceGenome:FB:FBgn0032482
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5547; Dmel\CG5547; pect; PECT
Summary
Enables ethanolamine-phosphate cytidylyltransferase activity. Involved in phosphatidylethanolamine biosynthetic process. Is active in cytosol. Is expressed in adult head and outer photoreceptor cell. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 82. Orthologous to human PCYT2 (phosphate cytidylyltransferase 2, ethanolamine). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Pect in Genome Data Viewer
Location:
34A9-34A9; 2-47 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13203762..13210828)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13203762..13210828)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Radial spoke head protein 1 Neighboring gene ER degradation enhancer, mannosidase alpha-like 2 Neighboring gene uncharacterized protein Neighboring gene small nuclear RNA U2 at 34AB a Neighboring gene uncharacterized protein Neighboring gene kekkon 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fat body phospholipid state dictates hunger-driven feeding behavior. Kelly KP, et al. Elife, 2022 Oct 6. PMID 36201241, Free PMC Article
  2. Wrapping axons in mammals and Drosophila: Different lipids, same principle. Murate M, et al. Biochimie, 2020 Nov. PMID 32800899
  3. A global in vivo Drosophila RNAi screen identifies a key role of ceramide phosphoethanolamine for glial ensheathment of axons. Ghosh A, et al. PLoS Genet, 2013. PMID 24348263, Free PMC Article
  4. Ceramide phosphoethanolamine, an enigmatic cellular membrane sphingolipid. Panevska A, et al. Biochim Biophys Acta Biomembr, 2019 Jul 1. PMID 31067435
  5. Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila. Lim HY, et al. Genes Dev, 2011 Jan 15. PMID 21245170, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PE homeostasis rebalanced through mitochondria-ER lipid exchange prevents retinal degeneration in Drosophila.
    Title: PE homeostasis rebalanced through mitochondria-ER lipid exchange prevents retinal degeneration in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ethanolamine-phosphate cytidylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ethanolamine-phosphate cytidylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ethanolamine-phosphate cytidylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ethanolamine-phosphate cytidylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylethanolamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylethanolamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylethanolamine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphoethanolamine cytidylyltransferase
Names
CG5547-PB
CG5547-PC
CG5547-PD
CG5547-PE
Pect-PB
Pect-PC
Pect-PD
Pect-PE
NP_609613.2
NP_723789.2
NP_723790.2
NP_723791.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13203762..13210828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165028.2 → NP_723789.2  phosphoethanolamine cytidylyltransferase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723789.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VK24, Q9VK25
    Related
    FBpp0080020
    Conserved Domains (3) summary
    PTZ00308
    Location:16 → 381
    PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional
    cd02173
    Location:223 → 373
    ECT; CTP:phosphoethanolamine cytidylyltransferase (ECT)
    cd02174
    Location:19 → 165
    CCT; CTP:phosphocholine cytidylyltransferase

  2. NM_165029.2 → NP_723790.2  phosphoethanolamine cytidylyltransferase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723790.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86PD6, Q8IP80
    Related
    FBpp0080022
    Conserved Domains (3) summary
    PTZ00308
    Location:16 → 369
    PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional
    cd02173
    Location:211 → 361
    ECT; CTP:phosphoethanolamine cytidylyltransferase (ECT)
    cd02174
    Location:19 → 165
    CCT; CTP:phosphocholine cytidylyltransferase

  3. NM_165030.2 → NP_723791.2  phosphoethanolamine cytidylyltransferase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723791.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IP79
    Related
    FBpp0080021
    Conserved Domains (3) summary
    PTZ00308
    Location:16 → 362
    PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional
    cd02173
    Location:204 → 354
    ECT; CTP:phosphoethanolamine cytidylyltransferase (ECT)
    cd02174
    Location:19 → 165
    CCT; CTP:phosphocholine cytidylyltransferase

  4. NM_135769.3 → NP_609613.2  phosphoethanolamine cytidylyltransferase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609613.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTB3
    Conserved Domains (3) summary
    PTZ00308
    Location:16 → 359
    PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional
    cd02173
    Location:201 → 351
    ECT; CTP:phosphoethanolamine cytidylyltransferase (ECT)
    cd02174
    Location:19 → 165
    CCT; CTP:phosphocholine cytidylyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KTB3 Q7KTB3
Q8IP79 Q8IP79
Q8IP80 Q8IP80
Q95SU1 Q95SU1
Q9VK25 Q9VK25

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