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CG6565 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34749, updated on 4-Jan-2025

Summary

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Official Symbol
CG6565provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032513
Locus tag
Dmel_CG6565
See related
AllianceGenome:FB:FBgn0032513
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6565
Summary
Predicted to enable lipid binding activity. Involved in inner mitochondrial membrane organization. Is active in mitochondrial membrane. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; gut section; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 2. Orthologous to human STARD7 (StAR related lipid transfer domain containing 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG6565 in Genome Data Viewer
Location:
34B8-34B8; 2-48 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13374019..13376404)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13374019..13376404)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B22 subunit Neighboring gene B double prime 1 Neighboring gene uncharacterized protein Neighboring gene Coat Protein (coatomer) beta'

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Genetic Mosaic Screen Reveals Ecdysone-Responsive Genes Regulating Drosophila Oogenesis. Ables ET, et al. G3 (Bethesda), 2016 Aug 9. PMID 27226164, Free PMC Article
  2. Phospholipids can regulate complex I assembly independent of their role in maintaining mitochondrial membrane integrity. Murari A, et al. Cell Rep, 2023 Aug 29. PMID 37516961, Free PMC Article
  3. Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease. Kim YW, et al. Alzheimers Dement, 2021 May. PMID 33576571, Free PMC Article
  4. Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneration. Nelson B, et al. Cell Death Differ, 2005 Aug. PMID 15861189
  5. Dynamics of Dark-Fly Genome Under Environmental Selections. Izutsu M, et al. G3 (Bethesda), 2015 Dec 4. PMID 26637434, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine transfer activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in inner mitochondrial membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG6565-PA
CG6565-PB
CG6565-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13374019..13376404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298962.1 → NP_001285891.1  uncharacterized protein Dmel_CG6565, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285891.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJZ2
    Conserved Domains (1) summary
    cd08911
    Location:170 → 377
    START_STARD7-like; Lipid-binding START domain of mammalian STARD7 and related proteins

  2. NM_001298963.1 → NP_001285892.1  uncharacterized protein Dmel_CG6565, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285892.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJZ2
    Conserved Domains (1) summary
    cd08911
    Location:170 → 377
    START_STARD7-like; Lipid-binding START domain of mammalian STARD7 and related proteins

  3. NM_135800.3 → NP_609644.1  uncharacterized protein Dmel_CG6565, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609644.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJZ2
    Related
    FBpp0080047
    Conserved Domains (1) summary
    cd08911
    Location:170 → 377
    START_STARD7-like; Lipid-binding START domain of mammalian STARD7 and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJZ2 Q9VJZ2

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