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Ing5 Inhibitor of growth family member 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34752, updated on 9-Dec-2024

Summary

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Official Symbol
Ing5provided by FlyBase
Official Full Name
Inhibitor of growth family member 5provided by FlyBase
Primary source
FLYBASE:FBgn0032516
Locus tag
Dmel_CG9293
See related
AllianceGenome:FB:FBgn0032516
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9293; Dmel\CG9293
Summary
Enables acetyltransferase activator activity. Predicted to be involved in regulation of DNA-templated transcription. Part of MOZ/MORF histone acetyltransferase complex. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Orthologous to several human genes including ING5 (inhibitor of growth family member 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ing5 in Genome Data Viewer
Location:
34B9-34B9; 2-48 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13385848..13387312, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13385848..13387312, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Coat Protein (coatomer) beta' Neighboring gene loquacious Neighboring gene antisense RNA:CR44599 Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L24 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fragile X protein controls the efficacy of mRNA transport in Drosophila neurons. Estes PS, et al. Mol Cell Neurosci, 2008 Oct. PMID 18655836
  2. The Enok acetyltransferase complex interacts with Elg1 and negatively regulates PCNA unloading to promote the G1/S transition. Huang F, et al. Genes Dev, 2016 May 15. PMID 27198229, Free PMC Article
  3. Analysis of a Drosophila amplicon in follicle cells highlights the diversity of metazoan replication origins. Kim JC, et al. Proc Natl Acad Sci U S A, 2011 Oct 4. PMID 21933960, Free PMC Article
  4. Fragile X protein functions with lgl and the par complex in flies and mice. Zarnescu DC, et al. Dev Cell, 2005 Jan. PMID 15621528
  5. Identification of novel Drosophila centromere-associated proteins. Barth TK, et al. Proteomics, 2014 Oct. PMID 24841622

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tctp, a unique Ing5-binding partner, inhibits the chromatin binding of Enok in Drosophila.
    Title: Tctp, a unique Ing5-binding partner, inhibits the chromatin binding of Enok in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acetyltransferase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
inhibitor of growth family member 5
Names
CG9293-PA
CG9293-PB
Ing5-PA
Ing5-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13385848..13387312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165042.3 → NP_723814.1  inhibitor of growth family member 5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723814.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IP71
    Related
    FBpp0080104
    Conserved Domains (3) summary
    COG5034
    Location:1 → 264
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15586
    Location:220 → 264
    PHD_ING4_5; PHD finger found in inhibitor of growth protein 4 (ING4) and 5 (ING5)
    pfam12998
    Location:6 → 108
    ING; Inhibitor of growth proteins N-terminal histone-binding

  2. NM_135803.4 → NP_609647.1  inhibitor of growth family member 5, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609647.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IP71, Q95RB4, Q9VJY8
    Related
    FBpp0080103
    Conserved Domains (3) summary
    COG5034
    Location:1 → 278
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15586
    Location:234 → 278
    PHD_ING4_5; PHD finger found in inhibitor of growth protein 4 (ING4) and 5 (ING5)
    pfam12998
    Location:6 → 108
    ING; Inhibitor of growth proteins N-terminal histone-binding
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJY8.2 Q9VJY8

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