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CG10859 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34756, updated on 9-Dec-2024

Summary

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Official Symbol
CG10859provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032520
Locus tag
Dmel_CG10859
See related
AllianceGenome:FB:FBgn0032520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10859
Summary
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in cilium movement and outer dynein arm assembly. Predicted to be part of outer dynein arm. Is expressed in adult head and spermatogonium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 9. Orthologous to human DNAI2 (dynein axonemal intermediate chain 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG10859 in Genome Data Viewer
Location:
34B10-34B10; 2-48 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13396392..13398664, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13396392..13398664, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L24 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44600 Neighboring gene uncharacterized protein Neighboring gene Vitelline membrane 34Ca

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A molecular genetic analysis of the interaction between the cytoplasmic dynein intermediate chain and the glued (dynactin) complex. Boylan K, et al. Mol Biol Cell, 2000 Nov. PMID 11071907, Free PMC Article
  2. Analysis of a Drosophila amplicon in follicle cells highlights the diversity of metazoan replication origins. Kim JC, et al. Proc Natl Acad Sci U S A, 2011 Oct 4. PMID 21933960, Free PMC Article
  3. Diverse Roles of Axonemal Dyneins in Drosophila Auditory Neuron Function and Mechanical Amplification in Hearing. Karak S, et al. Sci Rep, 2015 Nov 26. PMID 26608786, Free PMC Article
  4. Dyneins across eukaryotes: a comparative genomic analysis. Wickstead B, et al. Traffic, 2007 Dec. PMID 17897317, Free PMC Article
  5. Ciliary dynein motor preassembly is regulated by Wdr92 in association with HSP90 co-chaperone, R2TP. Zur Lage P, et al. J Cell Biol, 2018 Jul 2. PMID 29743191, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium movement ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of outer dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of outer dynein arm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10859-PA
CG10859-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13396392..13398664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135807.3 → NP_609651.1  uncharacterized protein Dmel_CG10859, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609651.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJY4
    Related
    FBpp0080100
    Conserved Domains (3) summary
    COG2319
    Location:261 → 512
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:284 → 332
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:279 → 492
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001298969.1 → NP_001285898.1  uncharacterized protein Dmel_CG10859, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285898.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJY4
    Conserved Domains (3) summary
    COG2319
    Location:261 → 512
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:284 → 332
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:279 → 492
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJY4 Q9VJY4

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