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B4 B4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34767, updated on 4-Jan-2025

Summary

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Official Symbol
B4provided by FlyBase
Official Full Name
B4provided by FlyBase
Primary source
FLYBASE:FBgn0023407
Locus tag
Dmel_CG9239
See related
AllianceGenome:FB:FBgn0023407
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
B4/Susi; BG:DS07660.4; CG9239; CG9260; Dmel\CG9239; n(2)05337; Susi
Summary
Involved in circadian rhythm and imaginal disc development. Located in plasma membrane. Is expressed in several structures, including adult brain; adult pars intercerebralis; embryonic/larval salivary gland; larval central nervous system; and somatic precursor cell. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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Location:
34C3-34C4; 2-48 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13500624..13549328, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13500624..13549328, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44973 Neighboring gene kuzbanian Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs. Sotillos S, et al. Development, 1997 Dec. PMID 9428413
  2. Susi, a negative regulator of Drosophila PI3-kinase. Wittwer F, et al. Dev Cell, 2005 Jun. PMID 15935772
  3. Development and diabetes on the fly. Murillo-Maldonado JM, et al. Mech Dev, 2017 Apr. PMID 27702607
  4. Misexpression screen for genes altering the olfactory map in Drosophila. Zhang D, et al. Genesis, 2006 Apr. PMID 16607613
  5. Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations. Jha AR, et al. Mol Biol Evol, 2016 Feb. PMID 26576852, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Susi, a negative regulator of Drosophila PI3-kinase
    Title: Susi, a negative regulator of Drosophila PI3-kinase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c13527561-13522313 mobile_element_type = transposon:Transpac{}362

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in imaginal disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
B4
Names
B4-PA
B4-PB
B4-PC
CG9239-PA
CG9239-PB
CG9239-PC
suppressor of signaling by insulin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13500624..13549328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273516.1 → NP_001260445.1  B4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260445.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16865, Q9VJX3

  2. NM_057977.4 → NP_477325.2  B4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477325.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16865, Q9VJX3
    Related
    FBpp0080091

  3. NM_165046.1 → NP_723823.1  B4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723823.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16865, Q9VJX3
    Related
    FBpp0080092, FBtr0080514
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O16865 O16865
Q9VJX3 Q9VJX3

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