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kuz kuzbanian [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34772, updated on 4-Jan-2025

Summary

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Official Symbol
kuzprovided by FlyBase
Official Full Name
kuzbanianprovided by FlyBase
Primary source
FLYBASE:FBgn0259984
Locus tag
Dmel_CG7147
See related
AllianceGenome:FB:FBgn0259984
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
11410; 34Da; ADAM10; BG:DS07660.3; br38; CG7147; CT22079; Dmel\CG7147; GS11410; Kuz; KUZ; l(2)03782; l(2)34Da; l(2)br38; l(2)c00136; l(2)k01403; l34Da; soy nut
Summary
Enables metalloendopeptidase activity. Involved in several processes, including border follicle cell migration; heart development; and nervous system development. Located in perivitelline space. Is expressed in several structures, including adult brain cell body rind; border follicle cell; embryonic/larval neuromuscular junction; epithelium; and imaginal disc. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See kuz in Genome Data Viewer
Location:
34C4-34C6; 2-48 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13550139..13639411)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13550139..13639411)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene B4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44973 Neighboring gene uncharacterized protein Neighboring gene mir-2489 stem loop Neighboring gene long non-coding RNA:CR43410 Neighboring gene long non-coding RNA:CR44726 Neighboring gene icarus

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. Yan Y, et al. J Cell Biol, 2002 Jul 22. PMID 12119356, Free PMC Article
  2. Natural and laboratory mutations in kuzbanian are associated with zinc stress phenotypes in Drosophila melanogaster. Le Manh H, et al. Sci Rep, 2017 Feb 20. PMID 28218276, Free PMC Article
  3. Snake venom, fertilization and neurogenesis. Yedvobnick B. Trends Neurosci, 1996 Dec. PMID 8961480
  4. ADAMs: focus on the protease domain. Black RA, et al. Curr Opin Cell Biol, 1998 Oct. PMID 9818177
  5. KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis. Rooke J, et al. Science, 1996 Aug 30. PMID 8703057

See all (231) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IMP regulates Notch signalling by controlling the localisation of Kuzbanian to the apical domain, where Notch cleavage occurs, revealing a novel regulatory step in the Notch pathway.
    Title: IMP regulates Kuzbanian to control the timing of Notch signalling in Drosophila follicle cells.
  2. indicates that KUZ is required to facilitate a functional Notch signal in the Notch-dependent cell for correct cell fate specification
    Title: On the roles of Notch, Delta, kuzbanian, and inscuteable during the development of Drosophila embryonic neuroblast lineages.
  3. Kuz regulates Notch signaling primarily by activating the Notch receptor and has little overall effect on signaling via disabling Delta.
    Title: Kuz and TACE can activate Notch independent of ligand.
  4. clonal analysis of kuz in Drosophila wing
    Title: kuzbanian is required cell autonomously during Notch signalling in the Drosophila wing.
  5. KUZ regulates the relay between the G protein-coupled receptors and EGF ereceptors signaling pathways
    Title: The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors.
  6. Kuzbanian acts during lateral inhibition within the cardiac primordium. Furthermore we discuss a second function of Kuzbanian in heart cell morphogenesis.
    Title: The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster.
  7. Notch activation and KUZ expression are restricted to border cells at stage 9 of oogenesis
    Title: Spatially localized Kuzbanian required for specific activation of Notch during border cell migration.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

mobile_element

  • Loc: 13560515-13565210 mobile_element_type = transposon:F{}kuz[F363]
  • Loc: 13611261-13611320 mobile_element_type = transposon:INE-1{}2292

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch receptor processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Notch receptor processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cardiocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in glial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lymph gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuroblast fate determination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pericardial nephrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Roundabout signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of axon extension TAS
Traceable Author Statement
more info
 PubMed 
involved_in ventral cord development HMP PubMed 
involved_in ventral cord development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perivitelline space HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kuzbanian
Names
CG7147-PA
CG7147-PB
CG7147-PC
CG7147-PF
CG7147-PG
kuz-PA
kuz-PB
kuz-PC
kuz-PF
kuz-PG
kuzbaninan
lethal (2) c00136
NP_001014481.1
NP_001097159.2
NP_001097160.2
NP_477187.1
NP_723825.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13550139..13639411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165047.3 → NP_723825.1  kuzbanian, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723825.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q94902, Q9VJW9
    Related
    FBpp0080088
    Conserved Domains (3) summary
    cd04270
    Location:410 → 677
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam00200
    Location:684 → 776
    Disintegrin; Disintegrin
    pfam13574
    Location:450 → 659
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like

  2. NM_001014481.3 → NP_001014481.1  kuzbanian, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014481.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q59DZ3, Q7YU78
    Conserved Domains (3) summary
    cd04270
    Location:410 → 677
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam00200
    Location:684 → 776
    Disintegrin; Disintegrin
    pfam13574
    Location:450 → 659
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like

  3. NM_057839.5 → NP_477187.1  kuzbanian, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477187.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q94902, Q9VJW9
    Related
    FBpp0080087
    Conserved Domains (3) summary
    cd04270
    Location:410 → 677
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam00200
    Location:684 → 776
    Disintegrin; Disintegrin
    pfam13574
    Location:450 → 659
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like

  4. NM_001103690.3 → NP_001097160.2  kuzbanian, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097160.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DZ02, Q94902
    Conserved Domains (3) summary
    cd04270
    Location:410 → 677
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam00200
    Location:684 → 776
    Disintegrin; Disintegrin
    pfam13574
    Location:450 → 659
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like

  5. NM_001103689.2 → NP_001097159.2  kuzbanian, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097159.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DZ03, Q94902
    Conserved Domains (3) summary
    cd04270
    Location:410 → 677
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam00200
    Location:684 → 776
    Disintegrin; Disintegrin
    pfam13574
    Location:450 → 659
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DZ02 A8DZ02
A8DZ03 A8DZ03
Q59DZ3 Q59DZ3
Q94902 Q94902
Q9VJW9 Q9VJW9

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