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Sos - Son of sevenless

Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; open tracheal system development; and positive regulation of small GTPase mediated signal transduction. Located in cytosol and rhabdomere microvillus membrane. Is extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including embryonic/larval tracheal section; larval central nervous system; organism subdivision; and spermatozoon. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); atrial heart septal defect; gingival fibromatosis; and pulmonary valve stenosis. Orthologous to several human genes including SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa