PolG1 DNA polymerase gamma subunit 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PolG1provided by FlyBase
Official Full Name: DNA polymerase gamma subunit 1provided by FlyBase
Primary source: FLYBASE:FBgn0004406
Locus tag: Dmel_CG8987
See related: AllianceGenome:FB:FBgn0004406
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 34Dc; AAC47658; anon-34Dc; BG:DS00941.6; br5; cDNA 2; CG8987; D-pol gamma-alpha; Dmel\CG8987; DmPolgammaA; DmPOLgammaA; DNApol-gamma; DNApol-gamma125; l(2)34Dc; l(2)br14; l(2)br5; l(2)brS; mtDNA pol; mtPolA; MtPolA; pol gamma; Pol gamma; pol gamma-alpha; Polg; PolG; POLG; PolgA; POLGalpha; polgamma; Polgamma; polgamma-alpha; Polgamma-alpha; tam; Tam
Summary: Enables 3'-5'-DNA exonuclease activity; DNA-directed DNA polymerase activity; and nucleotide binding activity. Involved in DNA replication proofreading and mitochondrion organization. Located in mitochondrial nucleoid. Part of gamma DNA polymerase complex. Used to study Alpers-Huttenlocher syndrome and mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in several diseases, including mitochondrial DNA depletion syndrome (multiple); mitochondrial myopathy (multiple); neurodegenerative disease (multiple); ovarian disease (multiple); and sensory ataxic neuropathy, dysarthria, and ophthalmoparesis. Orthologous to human POLG (DNA polymerase gamma, catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 34D1-34D1; 2-49 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (13823980..13827772, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (13823980..13827772, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of the nuclear-encoded mtDNA polymerase, Tamas, produces a more complete block of mtDNA elimination.
Title: The Mitochondrial DNA Polymerase Promotes Elimination of Paternal Mitochondrial Genomes.
Muscle-specific overexpression of the catalytic subunit of DNA polymerase gamma induces pupal lethality in Drosophila melanogaster.
Title: Muscle-specific overexpression of the catalytic subunit of DNA polymerase γ induces pupal lethality in Drosophila melanogaster.
DNA-binding mutants of mitochondrial single-stranded DNA-binding protein are defective in stimulation of DNA synthesis by pol gamma
Title: Physiological and biochemical defects in functional interactions of mitochondrial DNA polymerase and DNA-binding mutants of single-stranded DNA-binding protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-5'-DNA exonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables 3'-5'-DNA exonuclease activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed DNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-directed DNA polymerase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables DNA-directed DNA polymerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nucleotide binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication proofreading	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA replication proofreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA-templated DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial DNA replication	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion inheritance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of gamma DNA polymerase complex	IDA Inferred from Direct Assay more info	PubMed
part_of gamma DNA polymerase complex	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA polymerase gamma subunit 1

Names: CG8987-PA; DNA polymerase gamma; DNA polymerase gamma 125kD; PolG1-PA; alpha subunit; catalytic subunit of the mitochondrial DNA polymerase; catalytic(alpha)subunit; lethal 14 in the black-reduced region; lethal 5 in the black-reduced region; lethal(2)34Dc; mitochondrial gamma polymerase; mtDNA pol-gamma; mtDNA polymerase alpha; tamas

NP_476821.1

EC 2.7.7.7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

13823980..13827772 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057473.4 → NP_476821.1 DNA polymerase gamma subunit 1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476821.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B5RIX0, Q27607, Q8T4E6, Q94906, Q9V442

Related

FBpp0080148

Conserved Domains (3) summary

cd08641
Location:705 → 1107

DNA_pol_gammaA; Pol gammaA is a family A polymerase that is responsible for DNA replication and repair in mitochondria

pfam05438
Location:420 → 539

TRH; Thyrotropin-releasing hormone (TRH)

cl02626
Location:398 → 440

DNA_pol_A; Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication