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NimC4 Nimrod C4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34824, updated on 9-Dec-2024

Summary

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Official Symbol
NimC4provided by FlyBase
Official Full Name
Nimrod C4provided by FlyBase
Primary source
FLYBASE:FBgn0260011
Locus tag
Dmel_CG16876
See related
AllianceGenome:FB:FBgn0260011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS05899.3; CG16876; CT35247; Dmel\CG16876; nimC4; simu; Simu; SIMU
Summary
Enables phosphatidylserine binding activity. Involved in engulfment of apoptotic cell. Located in plasma membrane. Is expressed in several structures, including amnioserosa; embryonic/larval hemocyte; ganglia; glial cell; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See NimC4 in Genome Data Viewer
Location:
34F2-34F2; 2-50 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14047582..14048863)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14047582..14048863)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45284 Neighboring gene uncharacterized protein Neighboring gene nicotinic Acetylcholine Receptor alpha5 Neighboring gene heimdall Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Simu-dependent clearance of dying cells regulates macrophage function and inflammation resolution. Roddie HG, et al. PLoS Biol, 2019 May. PMID 31086359, Free PMC Article
  2. Keeping the CNS clear: glial phagocytic functions in Drosophila. Kurant E. Glia, 2011 Sep. PMID 21136555
  3. Glial Phagocytic Receptors Promote Neuronal Loss in Adult Drosophila Brain. Hakim-Mishnaevski K, et al. Cell Rep, 2019 Nov 5. PMID 31693886
  4. Overexposure to apoptosis via disrupted glial specification perturbs Drosophila macrophage function and reveals roles of the CNS during injury. Armitage EL, et al. Cell Death Dis, 2020 Aug 14. PMID 32796812, Free PMC Article
  5. Caspase activity is required for engulfment of apoptotic cells. Shklyar B, et al. Mol Cell Biol, 2013 Aug. PMID 23754750, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nimrod C4
Names
CG16876-PA
NimC4-PA
six microns under
six-microns-under

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    14047582..14048863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135854.3 → NP_609698.2  nimrod C4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609698.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SYU6, Q9V392
    Related
    FBpp0080169
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SYU6 Q8SYU6
Q9V392 Q9V392

Gene LinkOut

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