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CG33090 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34835, updated on 4-Jan-2025

Summary

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Official Symbol
CG33090provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0028916
Locus tag
Dmel_CG33090
See related
AllianceGenome:FB:FBgn0028916
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS01068.2; CG15287; CG31837; CG7469; Dmel\CG33090
Summary
Predicted to enable beta-glucosidase activity and glucosyltransferase activity. Predicted to be involved in bile acid metabolic process and glycoside catabolic process. Predicted to be located in membrane. Is expressed in adult head; embryonic/larval dorsal vessel; embryonic/larval mushroom body; larval central brain; and wing pouch. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 46. Orthologous to human GBA2 (glucosylceramidase beta 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG33090 in Genome Data Viewer
Location:
35A4-35A4; 2-50 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14334158..14345795)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14334158..14345795)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene wing blister Neighboring gene long non-coding RNA:CR43640 Neighboring gene male sterile (2) 34Fe Neighboring gene uncharacterized protein Neighboring gene Spermathecal endopeptidase 2 Neighboring gene mitochondrial transcription termination factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. G-TRACE: rapid Gal4-based cell lineage analysis in Drosophila. Evans CJ, et al. Nat Methods, 2009 Aug. PMID 19633663, Free PMC Article
  2. Developmental timing of a sensory-mediated larval surfacing behavior correlates with cessation of feeding and determination of final adult size. Wegman LJ, et al. Dev Biol, 2010 Sep 15. PMID 20630480, Free PMC Article
  3. Developmental ethanol exposure leads to dysregulation of lipid metabolism and oxidative stress in Drosophila. Logan-Garbisch T, et al. G3 (Bethesda), 2014 Nov 11. PMID 25387828, Free PMC Article
  4. The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis. Beckstead RB, et al. Genome Biol, 2005. PMID 16356271, Free PMC Article
  5. Nociceptor-Enriched Genes Required for Normal Thermal Nociception. Honjo K, et al. Cell Rep, 2016 Jul 12. PMID 27346357, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables beta-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-glucosidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glucosylceramidase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bile acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glucosylceramide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycoside catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG33090-PB
CG33090-PC
CG33090-PD
CG33090-PE
glucosylceramidase
NP_001285926.1
NP_001285927.1
NP_001285928.1
NP_788055.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    14334158..14345795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298999.1 → NP_001285928.1  uncharacterized protein Dmel_CG33090, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285928.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JAF7
    Conserved Domains (2) summary
    pfam04685
    Location:480 → 912
    DUF608; Protein of unknown function, DUF608
    pfam12215
    Location:132 → 420
    GBA2_N; beta-Glucocerebrosidase 2 N terminal

  2. NM_176041.2 → NP_788055.2  uncharacterized protein Dmel_CG33090, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788055.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RIG1, Q29R22, Q7KT91, Q95TX3
    Related
    FBpp0080197
    Conserved Domains (2) summary
    pfam04685
    Location:505 → 937
    DUF608; Protein of unknown function, DUF608
    pfam12215
    Location:132 → 445
    GBA2_N; beta-Glucocerebrosidase 2 N terminal

  3. NM_001298998.1 → NP_001285927.1  uncharacterized protein Dmel_CG33090, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285927.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J9U5
    Conserved Domains (2) summary
    pfam04685
    Location:503 → 935
    DUF608; Protein of unknown function, DUF608
    pfam12215
    Location:132 → 443
    GBA2_N; beta-Glucocerebrosidase 2 N terminal

  4. NM_001298997.1 → NP_001285926.1  uncharacterized protein Dmel_CG33090, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285926.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JE45
    Conserved Domains (2) summary
    pfam04685
    Location:356 → 788
    DUF608; Protein of unknown function, DUF608
    pfam12215
    Location:59 → 296
    GBA2_N; beta-Glucocerebrosidase 2 N terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KT91.1 Q7KT91
X2J9U5 X2J9U5
X2JAF7 X2JAF7
X2JE45 X2JE45

Gene LinkOut

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