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mTTF mitochondrial transcription termination factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34837, updated on 4-Jan-2025

Summary

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Official Symbol
mTTFprovided by FlyBase
Official Full Name
mitochondrial transcription termination factorprovided by FlyBase
Primary source
FLYBASE:FBgn0028530
Locus tag
Dmel_CG18124
See related
AllianceGenome:FB:FBgn0028530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS01068.4; CG18124; Dmel\CG18124; DmTTF; DS01068.4; TTF
Summary
Enables DNA binding activity. Involved in termination of mitochondrial transcription. Located in mitochondrion. Is expressed in adult head and spermatozoon. Orthologous to human MTERF1 (mitochondrial transcription termination factor 1) and MTERF2 (mitochondrial transcription termination factor 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See mTTF in Genome Data Viewer
Location:
35A4-35A4; 2-50 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14347239..14348790, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14347239..14348790, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Spermathecal endopeptidase 2 Neighboring gene antisense RNA:CR44850 Neighboring gene lethal (2) 34Fc Neighboring gene uncharacterized protein Neighboring gene lethal (2) 34Fd

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vitro transcription termination activity of the Drosophila mitochondrial DNA-binding protein DmTTF. Roberti M, et al. Biochem Biophys Res Commun, 2005 May 27. PMID 15845400
  2. The Drosophila termination factor DmTTF regulates in vivo mitochondrial transcription. Roberti M, et al. Nucleic Acids Res, 2006. PMID 16648357, Free PMC Article
  3. The Drosophila nuclear factor DREF positively regulates the expression of the mitochondrial transcription termination factor DmTTF. Fernández-Moreno MA, et al. Biochem J, 2009 Mar 1. PMID 19032147
  4. Mitochondrial transcription terminator family members mTTF and mTerf5 have opposing roles in coordination of mtDNA synthesis. Jõers P, et al. PLoS Genet, 2013. PMID 24068965, Free PMC Article
  5. DmTTF, a novel mitochondrial transcription termination factor that recognises two sequences of Drosophila melanogaster mitochondrial DNA. Roberti M, et al. Nucleic Acids Res, 2003 Mar 15. PMID 12626700, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mTerf5 knockdown led to enhanced replication pausing at mTTF binding sites, a decrease in fragile replication intermediates containing single-stranded segments, and the disappearance of species containing segments of RNA/DNA hybrid
    Title: Mitochondrial transcription terminator family members mTTF and mTerf5 have opposing roles in coordination of mtDNA synthesis.
  2. DmTTF might play multiple roles in the mtDNA transcription process, for which different levels of the protein with respect to mtRNApol are required.
    Title: The Drosophila nuclear factor DREF positively regulates the expression of the mitochondrial transcription termination factor DmTTF.
  3. The first ever-obtained evidence for an in vivo role of an animal mitochondrial transcription termination factor.
    Title: The Drosophila termination factor DmTTF regulates in vivo mitochondrial transcription.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in termination of mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in termination of mitochondrial transcription IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitochondrial transcription termination factor
Names
CG18124-PA
mTTF-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    14347239..14348790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135865.4 → NP_609709.1  mitochondrial transcription termination factor [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609709.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86LS0, Q9V3F3
    Related
    FBpp0080213
    Conserved Domains (1) summary
    cl19765
    Location:284 → 378
    mTERF; mTERF
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3F3.1 Q9V3F3

Gene LinkOut

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