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l(2)34Fd lethal (2) 34Fd [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34839, updated on 4-Jan-2025

Summary

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Official Symbol
l(2)34Fdprovided by FlyBase
Official Full Name
lethal (2) 34Fdprovided by FlyBase
Primary source
FLYBASE:FBgn0261535
Locus tag
Dmel_CG7516
See related
AllianceGenome:FB:FBgn0261535
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
A4; BG:DS01068.6; br15; CG7516; Dmel\CG7516; l(2)br15
Summary
Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleus. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; dorsal pharyngeal muscle cell; embryonic/larval midgut; and embryonic/larval midgut primordium. Orthologous to human NOL10 (nucleolar protein 10). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See l(2)34Fd in Genome Data Viewer
Location:
35A4-35A4; 2-50 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14352594..14355085, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14352594..14355085, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene mitochondrial transcription termination factor Neighboring gene antisense RNA:CR44850 Neighboring gene lethal (2) 34Fc Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44851 Neighboring gene Rab14 Neighboring gene antisense RNA:CR43463 Neighboring gene Polypeptide N-acetylgalactosaminyltransferase 35A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The molecular analysis of the el-noc complex of Drosophila melanogaster. Davis T, et al. Genetics, 1990 Sep. PMID 2121591, Free PMC Article
  2. Developmental timing of a sensory-mediated larval surfacing behavior correlates with cessation of feeding and determination of final adult size. Wegman LJ, et al. Dev Biol, 2010 Sep 15. PMID 20630480, Free PMC Article
  3. The genetics of a small chromosome region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. IV: scutoid, an antimorphic mutation. Ashburner M, et al. Genetics, 1982 Nov. PMID 6816673, Free PMC Article
  4. Genetic and cytogenetic analysis of the Adh region in Drosophila melanogaster. O'Donnell J, et al. Genetics, 1977 Jul. PMID 408228, Free PMC Article
  5. A novel transvection phenomenon affecting the white gene of Drosophila melanogaster. Gubb D, et al. Genetics, 1990 Sep. PMID 2121594, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lethal (2) 34Fd
Names
CG7516-PA
l(2)34Fd-PA
lethal 15 in the black-reduced region
lethal group A4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    14352594..14355085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135867.4 → NP_609711.1  lethal (2) 34Fd [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609711.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3P2
    Related
    FBpp0080211
    Conserved Domains (5) summary
    COG2319
    Location:38 → 338
    WD40; WD40 repeat [General function prediction only]
    pfam04514
    Location:396 → 584
    BTV_NS2; Bluetongue virus non-structural protein NS2
    pfam08159
    Location:476 → 503
    NUC153; NUC153 domain
    sd00039
    Location:179 → 215
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:149 → 329
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3P2 Q9V3P2

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