ppk pickpocket [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ppkprovided by FlyBase
Official Full Name: pickpocketprovided by FlyBase
Primary source: FLYBASE:FBgn0020258
Locus tag: Dmel_CG3478
See related: AllianceGenome:FB:FBgn0020258
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS06238.1; CG3478; dfr; dmdNaC1; dmdNaCl; Dmel\CG3478; mdNaC1; pkt; Ppk; PPK; ppk1; Ppk1; PPK1
Summary: Enables pH-gated monoatomic ion channel activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; mechanosensory behavior; and negative regulation of feeding behavior. Located in dendrite membrane. Part of monoatomic ion channel complex. Is expressed in several structures, including adult sex peptide sensory neurons; appendage; multidendritic neurons; neuron projection bundle; and sensory nervous system primordium. Orthologous to several human genes including ASIC1 (acid sensing ion channel subunit 1); ASIC2 (acid sensing ion channel subunit 2); and ASIC3 (acid sensing ion channel subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 35B1-35B1; 2-50 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (14378218..14381172, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (14378218..14381172, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

water,salt and pheromone sensing neurons that express members of the pickpocket families.
Title: Molecular neurobiology of Drosophila taste.
Deficiency of the mechanosensory ion channel PPK1 gene or RNAi knockdown of its expression in the PENS result in a similar increase in food intake, which can be rescued by expression of wild-type PPK1 in the same neurons.
Title: Regulation of food intake by mechanosensory ion channels in enteric neurons.
Balboa (also known as CG8546, ppk26) and PPK physically interact and likely form a functional ion channel. Both genes are functionally required for mechanical nociception and show very specific enrichment and expression in the class IV nociceptor neurons.
Title: Balboa binds to pickpocket in vivo and is required for mechanical nociception in Drosophila larvae.
Ppk26, a member of the trimeric degenerin/epithelial sodium channel (DEG/ENaC) family, is necessary for proper locomotion behavior in Drosophila larvae in a mutually dependent fashion with coexpressed Ppk1.
Title: Identification of Ppk26, a DEG/ENaC Channel Functioning with Ppk1 in a Mutually Dependent Manner to Guide Locomotion Behavior in Drosophila.
Presynaptic calcium imaging experiments support a model in which a PPK11- and PPK16-containing DEG/ENaC channel modulates presynaptic membrane voltage .
Title: A presynaptic ENaC channel drives homeostatic plasticity.
Ppk1 can function as an ionotropic molecular sensory transducer capable of transforming the perception of a stimulus into phasic neuronal activity in sensory neurons.
Title: Pickpocket1 is an ionotropic molecular sensory transducer.
class IV multiple-dendritic(mdIV) nociceptors are also required for a normal larval aversion to locomotion on to a dry surface environment utilizing painless and PPK1
Title: Drosophila nociceptors mediate larval aversion to dry surface environments utilizing both the painless TRP channel and the DEG/ENaC subunit, PPK1.
This study reported that the pickpocket is required for mechanical nociception but not thermal nociception in polymodal nociceptors.
Title: Pickpocket is a DEG/ENaC protein required for mechanical nociception in Drosophila larvae.
Results demonstrate a key role for the PPK1 sensory neurons in regulation of important behavioral transitions associated with developmental progression of larvae from foraging to wandering stage.
Title: Sensory mechanisms controlling the timing of larval developmental and behavioral transitions require the Drosophila DEG/ENaC subunit, Pickpocket1.
plays an essential role in controlling rhythmic locomotion
Title: Enhanced locomotion caused by loss of the Drosophila DEG/ENaC protein Pickpocket1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables pH-gated monoatomic ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sodium channel activity	IEA Inferred from Electronic Annotation more info
enables sodium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of pain	IEP Inferred from Expression Pattern more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of temperature stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proprioception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in dendrite membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of monoatomic ion channel complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info