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IGFBP2 insulin like growth factor binding protein 2 [ Homo sapiens (human) ]

Gene ID: 3485, updated on 27-Nov-2024

Summary

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Official Symbol
IGFBP2provided by HGNC
Official Full Name
insulin like growth factor binding protein 2provided by HGNC
Primary source
HGNC:HGNC:5471
See related
Ensembl:ENSG00000115457 MIM:146731; AllianceGenome:HGNC:5471
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IBP2; IGF-BP53
Summary
The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Broad expression in liver (RPKM 67.6), stomach (RPKM 67.2) and 20 other tissues See more
Orthologs
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Genomic context

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See IGFBP2 in Genome Data Viewer
Location:
2q35
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (216632828..216664436)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (217115243..217146861)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (217497551..217529159)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7775 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:217485350-217485850 Neighboring gene uncharacterized LOC124907977 Neighboring gene proteasome subunit beta 3 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:217508368-217508942 Neighboring gene uncharacterized LOC124900515 Neighboring gene insulin like growth factor binding protein 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12306 Neighboring gene IGFBP5 antisense RNA 1 Neighboring gene ribosomal protein L31 pseudogene 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Comparison of Different Cytokine Conditions Reveals Resveratrol as a New Molecule for Ex Vivo Cultivation of Cord Blood-Derived Hematopoietic Stem Cells. Heinz N, et al. Stem Cells Transl Med, 2015 Sep. PMID 26160960, Free PMC Article
  2. Insulin-like growth factor binding protein 2 promotes glioma development and progression. Dunlap SM, et al. Proc Natl Acad Sci U S A, 2007 Jul 10. PMID 17606927, Free PMC Article
  3. Insulin-like growth factor binding protein-2 regulates β-catenin signaling pathway in glioma cells and contributes to poor patient prognosis. Patil SS, et al. Neuro Oncol, 2016 Nov. PMID 27044294, Free PMC Article
  4. Roles of insulin-like growth factor binding protein-2 (IGFBP-2) in glioblastoma. Fukushima T, et al. Anticancer Res, 2007 Nov-Dec. PMID 17970029
  5. Cooperativity of the N- and C-terminal domains of insulin-like growth factor (IGF) binding protein 2 in IGF binding. Kuang Z, et al. Biochemistry, 2007 Dec 4. PMID 17985932

See all (302) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Age-Related Increases in IGFBP2 Increase Melanoma Cell Invasion and Lipid Synthesis.
    Title: Age-Related Increases in IGFBP2 Increase Melanoma Cell Invasion and Lipid Synthesis.
  2. A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion.
    Title: A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion.
  3. IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer.
    Title: IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer.
  4. Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains.
    Title: Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains.
  5. Exosomal IGFBP2 derived from highly metastatic promotes hepatocellular carcinoma metastasis by inducing epithelial mesenchymal transition.
    Title: Exosomal IGFBP2 derived from highly metastatic promotes hepatocellular carcinoma metastasis by inducing epithelial mesenchymal transition.
  6. The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway.
    Title: The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway.
  7. Role of increased IGFBP2 in trophoblast cell proliferation and recurrent spontaneous abortion development: A pilot study.
    Title: Role of increased IGFBP2 in trophoblast cell proliferation and recurrent spontaneous abortion development: A pilot study.
  8. Cancer-associated fibroblast-associated gene IGFBP2 promotes glioma progression through induction of M2 macrophage polarization.
    Title: Cancer-associated fibroblast-associated gene IGFBP2 promotes glioma progression through induction of M2 macrophage polarization.
  9. METTL3-mediated HOTAIRM1 promotes vasculogenic mimicry icontributionsn glioma via regulating IGFBP2 expression.
    Title: METTL3-mediated HOTAIRM1 promotes vasculogenic mimicry icontributionsn glioma via regulating IGFBP2 expression.
  10. Insulin-like growth factor binding protein-2 as a biomarker for lupus nephritis.
    Title: Insulin-like growth factor binding protein-2 as a biomarker for lupus nephritis.
Submit: New GeneRIF Correction See all GeneRIFs (237)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpu vpu The gene expression of insulin-like growth factor binding protein 2 (IGFBP2) increases in cells infected with vpu-deficient HIV-1 compared to cells infected with the wild-type virus, indicating that HIV-1 Vpu downregulates IGFBP2 protein expression PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables insulin-like growth factor I binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables insulin-like growth factor I binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables insulin-like growth factor II binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables insulin-like growth factor II binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables receptor ligand inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
 PubMed 
enables signaling receptor inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in osteoblast differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of activated T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of insulin-like growth factor receptor signaling pathway IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of insulin-like growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
  
involved_in response to estrogen IEA
Inferred from Electronic Annotation
more info
  
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
  
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in response to nutrient IEA
Inferred from Electronic Annotation
more info
  
involved_in response to retinoic acid IEA
Inferred from Electronic Annotation
more info
  
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
insulin-like growth factor-binding protein 2
Names
IGF-binding protein 2
insulin-like growth factor binding protein 2, 36kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000597.3 → NP_000588.3  insulin-like growth factor-binding protein 2 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC071967, M35410
    Consensus CDS
    CCDS42815.1
    UniProtKB/Swiss-Prot
    P18065, Q14619, Q9UCL3
    Related
    ENSP00000233809.4, ENST00000233809.9
    Conserved Domains (2) summary
    smart00121
    Location:40 → 132
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:227 → 306
    Thyroglobulin_1; Thyroglobulin type-1 repeat

  2. NM_001313990.2 → NP_001300919.1  insulin-like growth factor-binding protein 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC007563, BC004312, BE735562
    Consensus CDS
    CCDS82570.1
    UniProtKB/TrEMBL
    C9JMY1
    Related
    ENSP00000389646.1, ENST00000456764.1
    Conserved Domains (1) summary
    pfam00086
    Location:83 → 162
    Thyroglobulin_1; Thyroglobulin type-1 repeat

  3. NM_001313992.2 → NP_001300921.1  insulin-like growth factor-binding protein 2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    BC004312, CV810939
    UniProtKB/Swiss-Prot
    P18065
    Conserved Domains (1) summary
    cd00191
    Location:60 → 140
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

  4. NM_001313993.2 → NP_001300922.1  insulin-like growth factor-binding protein 2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate exon in place of the first exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AC073321, BC004312, CN431340
    UniProtKB/Swiss-Prot
    P18065
    Conserved Domains (1) summary
    cd00191
    Location:60 → 140
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    216632828..216664436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    217115243..217146861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18065.2 GenPept UniProtKB/Swiss-Prot:P18065

Gene LinkOut

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