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LNP1 leukemia NUP98 fusion partner 1 [ Homo sapiens (human) ]

Gene ID: 348801, updated on 27-Nov-2024

Summary

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Official Symbol
LNP1provided by HGNC
Official Full Name
leukemia NUP98 fusion partner 1provided by HGNC
Primary source
HGNC:HGNC:28014
See related
Ensembl:ENSG00000206535 AllianceGenome:HGNC:28014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NP3
Expression
Broad expression in testis (RPKM 17.5), kidney (RPKM 4.6) and 20 other tissues See more
Orthologs
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Genomic context

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See LNP1 in Genome Data Viewer
Location:
3q12.2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (100401539..100456319)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (103106541..103161683)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (100120383..100175163)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:100053369-100053937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20155 Neighboring gene Sharpr-MPRA regulatory region 4023 Neighboring gene nitrilase family member 2 Neighboring gene translocase of outer mitochondrial membrane 70 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100118351-100119270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14571 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20158 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100126809-100127334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100127335-100127860 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100170016-100170553 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:100184868-100185368 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:100195719-100196404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14573 Neighboring gene transmembrane protein 45A Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100280470-100281334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20161 Neighboring gene adhesion G protein-coupled receptor G7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20162 Neighboring gene glia maturation factor beta pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique. Romana SP, et al. Leukemia, 2006 Apr. PMID 16467868
  2. NUP98 fusion oncoproteins interact with the APC/C(Cdc20) as a pseudosubstrate and prevent mitotic checkpoint complex binding. Salsi V, et al. Cell Cycle, 2016 Sep. PMID 27097363, Free PMC Article
  3. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). Zhu J, et al. Nat Biotechnol, 2013 Apr. PMID 23503679, Free PMC Article
  4. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
leukemia NUP98 fusion partner 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085451.2 → NP_001078920.1  leukemia NUP98 fusion partner 1

    See identical proteins and their annotated locations for NP_001078920.1

    Status: VALIDATED

    Source sequence(s)
    BC040562
    Consensus CDS
    CCDS43120.1
    UniProtKB/Swiss-Prot
    A1A4G5, B7ZLT3
    UniProtKB/TrEMBL
    C9J587
    Related
    ENSP00000373191.3, ENST00000383693.8
    Conserved Domains (1) summary
    pfam15419
    Location:11 → 175
    LNP1; Leukemia NUP98 fusion partner 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    100401539..100456319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    103106541..103161683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346440.1 → XP_054202415.1  leukemia NUP98 fusion partner 1 isoform X1

    UniProtKB/TrEMBL
    B3KPG3

  2. XM_054346441.1 → XP_054202416.1  leukemia NUP98 fusion partner 1 isoform X2

    UniProtKB/Swiss-Prot
    A1A4G5, B7ZLT3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1A4G5.1 GenPept UniProtKB/Swiss-Prot:A1A4G5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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