ZnT35C Zinc transporter 35C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ZnT35Cprovided by FlyBase
Official Full Name: Zinc transporter 35Cprovided by FlyBase
Primary source: FLYBASE:FBgn0028516
Locus tag: Dmel_CG3994
See related: AllianceGenome:FB:FBgn0028516
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS07295.1; cg3994; CG3994; Dmel\CG3994; dZnT35C; znt35C; ZNT35C
Summary: Enables zinc efflux transmembrane transporter activity. Involved in detoxification of zinc ion; intracellular zinc ion homeostasis; and zinc ion transmembrane transport. Located in apical plasma membrane. Is expressed in several structures, including Malpighian tubule primordium; adult head; epithelial tube; sensory nervous system primordium; and yolk nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including SLC30A3 (solute carrier family 30 member 3) and SLC30A8 (solute carrier family 30 member 8). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (15228728..15247714, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (15228728..15247714, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

ZnT35C is involved in cellular and organismal zinc efflux and plays a major role in zinc detoxification.
Title: Transcriptome response to heavy metal stress in Drosophila reveals a new zinc transporter that confers resistance to zinc.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables zinc efflux transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IC Inferred by Curator more info	PubMed

Process	Evidence Code	Pubs
involved_in detoxification of zinc ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular zinc ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
involved_in response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to zinc ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain