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esg escargot [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34903, updated on 9-Dec-2024

Summary

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Official Symbol
esgprovided by FlyBase
Official Full Name
escargotprovided by FlyBase
Primary source
FLYBASE:FBgn0287768
Locus tag
Dmel_CG3758
See related
AllianceGenome:FB:FBgn0287768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4B7; BG01042; BG:DS07851.7; br43; CG3758; dgl; Dmel\CG3758; Esg; flg; l(2)07082; l(2)35Ce; l(2)4B7; l(2)br43; l(2)esg; l35Ce; shof; wiz
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including nervous system development; open tracheal system development; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryonic imaginal tissue; epithelium; gut section; larval imaginal tissue; and somatic precursor cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See esg in Genome Data Viewer
Location:
35D2-35D2; 2-51 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15333866..15336138)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15333866..15336138)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene no hitter Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44859

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Independently paced Ca2+ oscillations in progenitor and differentiated cells in an ex vivo epithelial organ. Kim AA, et al. J Cell Sci, 2022 Jul 15. PMID 35722729, Free PMC Article
  2. Probe-Seq enables transcriptional profiling of specific cell types from heterogeneous tissue by RNA-based isolation. Amamoto R, et al. Elife, 2019 Dec 9. PMID 31815670, Free PMC Article
  3. Identification of an α-MoRF in the Intrinsically Disordered Region of the Escargot Transcription Factor. Hernández-Segura T, et al. ACS Omega, 2020 Jul 28. PMID 32743208, Free PMC Article
  4. Reduced Neuronal Transcription of Escargot, the Drosophila Gene Encoding a Snail-Type Transcription Factor, Promotes Longevity. Symonenko AV, et al. Front Genet, 2018. PMID 29760717, Free PMC Article
  5. Fate mapping of Drosophila embryonic mitotic domain 20 reveals that the larval visual system is derived from a subdomain of a few cells. Namba R, et al. Dev Biol, 1999 Aug 15. PMID 10433835

See all (453) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Experimental validation and characterization of putative targets of Escargot and STAT, two master regulators of the intestinal stem cells in Drosophila melanogaster.
    Title: Experimental validation and characterization of putative targets of Escargot and STAT, two master regulators of the intestinal stem cells in Drosophila melanogaster.
  2. Cell polarity opposes Jak/STAT-mediated Escargot activation that drives intratumor heterogeneity in a Drosophila tumor model.
    Title: Cell polarity opposes Jak/STAT-mediated Escargot activation that drives intratumor heterogeneity in a Drosophila tumor model.
  3. Results show that both Esg and Sc bind to a common promoter region of pros. Moreover, antagonistic activity between Esg and Sc controls the expression status of Pros in stem cells, thereby, specifying whether stem cells remain undifferentiated or commit to enteroendocrine cell differentiation.
    Title: Transcription Factor Antagonism Controls Enteroendocrine Cell Specification from Intestinal Stem Cells.
  4. Esg controls specification of cell types in trachea and suppresses ERK signaling in fusion cells to control cells' differential migratory behavior.
    Title: Escargot controls the sequential specification of two tracheal tip cell types by suppressing FGF signaling in Drosophila.
  5. Escargot and Scratch regulate neural commitment by antagonizing Notch activity in Drosophila sensory organs
    Title: Escargot and Scratch regulate neural commitment by antagonizing Notch activity in Drosophila sensory organs.
  6. CySCs mutant for esg are not maintained as stem cells, but remain capable of differentiating normally along the cyst cell lineage. In contrast, esg mutant CySCs that give rise to a closely related lineage, the apical hub cells, cannot maintain hub cell identity. this dual regulatory role is due to simultaneous control by Esg of overlapping genetic programs. Similar results were obtained with intestinal stem cells.
    Title: Simultaneous control of stemness and differentiation by the transcription factor Escargot in adult stem cells: How can we tease them apart?
  7. Robust intestinal homeostasis relies on cellular plasticity in enteroblasts mediated by miR-8-Escargot switch.
    Title: Robust intestinal homeostasis relies on cellular plasticity in enteroblasts mediated by miR-8-Escargot switch.
  8. Cell type-specific transcriptome analysis combined with Dam-ID binding studies identified Esg as a major repressor of differentiation genes in stem and progenitor cells.
    Title: Escargot maintains stemness and suppresses differentiation in Drosophila intestinal stem cells.
  9. Authors demonstrate that Esg plays a pivotal role in intestinal homeostasis, maintaining the stem cell pool while influencing fate decisions through modulation of Notch activity.
    Title: Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot.
  10. Escargot protein as an essential factor is required in hub cells for maintaining niche integrity by blocking conversion of hub cells to the cyst cell lineage.
    Title: Escargot restricts niche cell to stem cell conversion in the Drosophila testis.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in asymmetric neuroblast division IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in branch fusion, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell migration, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in genital disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gravitaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intestinal stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of imaginal histoblast diploidy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of compound eye pigmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to nicotine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
escargot
Names
CG3758-PA
D.m.Escargot
Fusion-1
double glazed
esg-PA
esgargot
fleabag
shut off
wizard

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    15333866..15336138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057252.4 → NP_476600.1  escargot [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476600.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25932, Q8SYF2, Q9V3E1
    UniProtKB/TrEMBL
    H9ZJM4
    Related
    FBpp0080293
    Conserved Domains (4) summary
    sd00017
    Location:372 → 392
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:311 → 331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:398 → 420
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:385 → 408
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25932.2 P25932
Q3YND2 Q3YND2

Gene LinkOut

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