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FOXD4L4 forkhead box D4 like 4 [ Homo sapiens (human) ]

Gene ID: 349334, updated on 10-Dec-2024

Summary

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Official Symbol
FOXD4L4provided by HGNC
Official Full Name
forkhead box D4 like 4provided by HGNC
Primary source
HGNC:HGNC:23762
See related
Ensembl:ENSG00000184659 MIM:611085; AllianceGenome:HGNC:23762
Gene type
protein coding
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FOXD4b; FOXD4L2; bA460E7.2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FOXD4L4 in Genome Data Viewer
Location:
9q21.11
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (65737146..65738396)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (80057244..80058494, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (70427649..70428899, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene FSHD region gene 1 family member K, pseudogene Neighboring gene Zn regulated GTPase metalloprotein activator 1E Neighboring gene Sharpr-MPRA regulatory region 13873 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:70489243-70489833 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:70450935-70451544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:70427620-70428156 Neighboring gene immunoglobulin kappa variable 1/OR-3 (pseudogene) Neighboring gene uncharacterized LOC101928381

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines. Freyaldenhoven BS, et al. Gene, 2002 Jul 10. PMID 12234674
  2. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. Fan Y, et al. Genome Res, 2002 Nov. PMID 12421752, Free PMC Article
  3. Diverse fates of paralogs following segmental duplication of telomeric genes. Wong A, et al. Genomics, 2004 Aug. PMID 15233989
  4. A census of human transcription factors: function, expression and evolution. Vaquerizas JM, et al. Nat Rev Genet, 2009 Apr. PMID 19274049
  5. Toward a complete human genome sequence. Sanger Center, et al. Genome Res, 1998 Nov. PMID 9847074

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
forkhead box protein D4-like 4
Names
FOXD4-like 4
forkhead box D4-like 2
forkhead box protein D4-like 2
forkhead box protein D4b
myeloid factor-gamma
winged helix factor-1
winged helix transcription factor beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199244.3 → NP_954714.2  forkhead box protein D4-like 4

    See identical proteins and their annotated locations for NP_954714.2

    Status: INFERRED

    Source sequence(s)
    BX284632
    Consensus CDS
    CCDS75845.1
    UniProtKB/Swiss-Prot
    Q5RIB4, Q6VB85, Q8WXT5
    UniProtKB/TrEMBL
    Q3MI95
    Related
    ENSP00000366630.1, ENST00000377413.3
    Conserved Domains (1) summary
    pfam00250
    Location:108 → 194
    Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    65737146..65738396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    80057244..80058494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001099279.1: Suppressed sequence

    Description
    NM_001099279.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this FOXD4-like family member.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WXT5.2 GenPept UniProtKB/Swiss-Prot:Q8WXT5

Gene LinkOut

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