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Ca-alpha1D Ca[2+]-channel protein alpha[[1]] subunit D [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34950, updated on 4-Jan-2025

Summary

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Official Symbol
Ca-alpha1Dprovided by FlyBase
Official Full Name
Ca[2+]-channel protein alpha[[1]] subunit Dprovided by FlyBase
Primary source
FLYBASE:FBgn0001991
Locus tag
Dmel_CG4894
See related
AllianceGenome:FB:FBgn0001991
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
A1D; alpha1; alpha1D; BG:DS02795.1; Ca-a1D; Ca-alpha1; ca-alpha1d; ca-alpha1D; Ca-Alpha1D; Ca-alphaID; Ca-alpha[[1]]D; Ca-_1D; Ca1D; Caalpha1D; cad; CAD; caID; Ca_alpha1D; CG4894; D-type Ca[2+]; DmCa1alpha1; dmca1D; Dmca1D; DmCa1D; Dmel\CG4894; DroCa1; l(2)35Fa; l35Fa
Summary
Enables voltage-gated calcium channel activity. Involved in several processes, including detection of temperature stimulus involved in sensory perception of pain; epithelial fluid transport; and neuron remodeling. Located in apical plasma membrane and basolateral plasma membrane. Part of voltage-gated calcium channel complex. Is expressed in adult head; organism; presumptive embryonic/larval nervous system; and spermatozoon. Human ortholog(s) of this gene implicated in several diseases, including Brugada syndrome 3; Timothy syndrome; eye disease (multiple); hypokalemic periodic paralysis; and muscle tissue disease (multiple). Orthologous to several human genes including CACNA1C (calcium voltage-gated channel subunit alpha1 C); CACNA1F (calcium voltage-gated channel subunit alpha1 F); and CACNA1S (calcium voltage-gated channel subunit alpha1 S). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ca-alpha1D in Genome Data Viewer
Location:
35E5-35E6; 2-51 cM
Exon count:
38
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16165831..16190540)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16165831..16190540)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44871 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43806 Neighboring gene long non-coding RNA:CR44734 Neighboring gene long non-coding RNA:CR44735

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence of more ion channels inhibited by celecoxib: KV1.3 and L-type Ca(2+) channels. Frolov RV, et al. BMC Res Notes, 2015 Mar 1. PMID 25889233, Free PMC Article
  2. The Dmca1D channel mediates Ca(2+) inward currents in Drosophila embryonic muscles. Hara Y, et al. J Neurogenet, 2015. PMID 26004544
  3. Dendritic and Axonal L-Type Calcium Channels Cooperate to Enhance Motoneuron Firing Output during Drosophila Larval Locomotion. Kadas D, et al. J Neurosci, 2017 Nov 8. PMID 28986465, Free PMC Article
  4. Cloning and characterization of a calcium channel alpha 1 subunit from Drosophila melanogaster with similarity to the rat brain type D isoform. Zheng W, et al. J Neurosci, 1995 Feb. PMID 7869089, Free PMC Article
  5. Focal laser stimulation of fly nociceptors activates distinct axonal and dendritic Ca(2+) signals. Basak R, et al. Biophys J, 2021 Aug 3. PMID 34175294, Free PMC Article

See all (138) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Separation of presynaptic Cav2 and Cav1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca(2+) pump PMCA.
    Title: Separation of presynaptic Ca(v)2 and Ca(v)1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca(2+) pump PMCA.
  2. Stac protein regulates release of neuropeptides.
    Title: Stac protein regulates release of neuropeptides.
  3. Co-immunoprecipitation analysis supports association between Ma2/d and Amph, and indirectly with Msp300. Ma2/d, in association with Msp300 and Amph, mediates interactions between the SR and the nuclear membrane.
    Title: Ma2/d promotes myonuclear positioning and association with the sarcoplasmic reticulum.
  4. maximum intraburst firing rates require axonal calcium influx through Dmca1D channels, likely to enhance sodium channel de-inactivation via a fast afterhyperpolarization through BK channel activation
    Title: Dendritic and Axonal L-Type Calcium Channels Cooperate to Enhance Motoneuron Firing Output during Drosophila Larval Locomotion.
  5. The Ca(2+) current in the embryonic muscle was completely eliminated in Dmca1D mutants, indicating that the Dmca1D-encoded Ca(2+) channel is the major mediator of inward currents in the body wall muscles throughout the embryonic and larval stages.
    Title: The Dmca1D channel mediates Ca(2+) inward currents in Drosophila embryonic muscles.
  6. cac and Dmca1D Ca(2+) channels differentially contribute to functional and structural aspects of slo-induced synaptic modifications
    Title: Distinct roles of Drosophila cacophony and Dmca1D Ca(2+) channels in synaptic homeostasis: genetic interactions with slowpoke Ca(2+) -activated BK channels in presynaptic excitability and postsynaptic response.
  7. The study indicated that alpha(2)delta proteins have functions that are independent of their roles in the biophysics and localization of Ca(2+) channels and that synaptic architecture depends on these functions.
    Title: Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions.
  8. This is the first characterization of an alpha2delta-3 mutant in any organism and indicates a necessary role for alpha2delta-3 in presynaptic vesicle release and calcium channel expression at active zones.
    Title: Mutations in a Drosophila alpha2delta voltage-gated calcium channel subunit reveal a crucial synaptic function.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables high voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables voltage-gated calcium channel activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium ion transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of temperature stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial fluid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epithelial fluid transport IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle contraction TAS
Traceable Author Statement
more info
 PubMed 
involved_in neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated calcium channel complex IGI
Inferred from Genetic Interaction
more info
 PubMed 
part_of voltage-gated calcium channel complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Ca[2+]-channel protein alpha[[1]] subunit D
Names
CG4894-PF
CG4894-PG
CG4894-PH
CG4894-PI
CG4894-PJ
CG4894-PK
CG4894-PL
CG4894-PM
CG4894-PN
CG4894-PO
Ca-alpha1D-PF
Ca-alpha1D-PG
Ca-alpha1D-PH
Ca-alpha1D-PI
Ca-alpha1D-PJ
Ca-alpha1D-PK
Ca-alpha1D-PL
Ca-alpha1D-PM
Ca-alpha1D-PN
Ca-alpha1D-PO
Ca2+-channel protein alpha1 subunit D
Ca[2+]-channel alpha1 subunit
alpha-1 subunit Ca2[+] channel type D
calcium channel alpha-1 subunit
drosophila melanogaster calcium channel alpha[[1]] subunit DHP-sensitive

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16165831..16190540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273556.1 → NP_001260485.1  Ca[2+]-channel protein alpha[[1]] subunit D, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260485.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
    UniProtKB/TrEMBL
    M9PDI5
    Conserved Domains (4) summary
    pfam00520
    Location:1223 → 1480
    Ion_trans; Ion transport protein
    pfam08763
    Location:1553 → 1625
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1843 → 1924
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1488 → 1551
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  2. NM_001273555.1 → NP_001260484.1  Ca[2+]-channel protein alpha[[1]] subunit D, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260484.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
    UniProtKB/TrEMBL
    M9PD04
    Conserved Domains (4) summary
    pfam00520
    Location:1190 → 1447
    Ion_trans; Ion transport protein
    pfam08763
    Location:1520 → 1592
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1810 → 1891
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1455 → 1518
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  3. NM_001273552.1 → NP_001260481.1  Ca[2+]-channel protein alpha[[1]] subunit D, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260481.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
    UniProtKB/TrEMBL
    M9PD78
    Conserved Domains (4) summary
    pfam00520
    Location:1187 → 1444
    Ion_trans; Ion transport protein
    pfam08763
    Location:1517 → 1589
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1807 → 1888
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1452 → 1515
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  4. NM_001273553.1 → NP_001260482.1  Ca[2+]-channel protein alpha[[1]] subunit D, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260482.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFZ4
    Conserved Domains (3) summary
    pfam00520
    Location:1187 → 1444
    Ion_trans; Ion transport protein
    pfam08763
    Location:1517 → 1589
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:1452 → 1515
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  5. NM_001273554.1 → NP_001260483.1  Ca[2+]-channel protein alpha[[1]] subunit D, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260483.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
    UniProtKB/TrEMBL
    M9PBC0
    Conserved Domains (4) summary
    pfam00520
    Location:1187 → 1444
    Ion_trans; Ion transport protein
    pfam08763
    Location:1517 → 1589
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16885
    Location:1807 → 1888
    CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
    pfam16905
    Location:1452 → 1515
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  6. NM_134429.3 → NP_602305.2  Ca[2+]-channel protein alpha[[1]] subunit D, isoform K [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
    Conserved Domains (3) summary
    pfam00520
    Location:767 → 1042
    Ion_trans; Ion transport protein
    pfam08763
    Location:2163 → 2235
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:2099 → 2152
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  7. NM_165147.2 → NP_723953.2  Ca[2+]-channel protein alpha[[1]] subunit D, isoform N [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
    Conserved Domains (3) summary
    pfam00520
    Location:767 → 1042
    Ion_trans; Ion transport protein
    pfam08763
    Location:2163 → 2235
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:2099 → 2152
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  8. NM_080365.3 → NP_525104.3  Ca[2+]-channel protein alpha[[1]] subunit D, isoform L [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
    Conserved Domains (3) summary
    pfam00520
    Location:767 → 1042
    Ion_trans; Ion transport protein
    pfam08763
    Location:2166 → 2238
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:2102 → 2155
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  9. NM_001273551.1 → NP_001260480.2  Ca[2+]-channel protein alpha[[1]] subunit D, isoform O [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
    UniProtKB/TrEMBL
    M9PDI1
    Conserved Domains (3) summary
    pfam00520
    Location:799 → 1074
    Ion_trans; Ion transport protein
    pfam08763
    Location:2192 → 2267
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:2129 → 2182
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

  10. NM_165146.2 → NP_723952.2  Ca[2+]-channel protein alpha[[1]] subunit D, isoform M [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
    Conserved Domains (3) summary
    pfam00520
    Location:767 → 1042
    Ion_trans; Ion transport protein
    pfam08763
    Location:2199 → 2271
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:2135 → 2188
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBC0 M9PBC0
M9PD04 M9PD04
M9PD78 M9PD78
M9PDI1 M9PDI1
M9PDI5 M9PDI5
M9PFZ4 M9PFZ4
Q24270.2 Q24270

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