chif chiffon [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: chifprovided by FlyBase
Official Full Name: chiffonprovided by FlyBase
Primary source: FLYBASE:FBgn0000307
Locus tag: Dmel_CG5813
See related: AllianceGenome:FB:FBgn0000307
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS09218.1; BG:DS09218.2; CG5813; CG5817; chf; Chif; Chiffon; Dbf4; Dmel\CG5813; DS09218.1; fs(2)chiffon
Summary: Enables protein kinase activator activity. Involved in several processes, including eggshell chorion gene amplification; muscle cell cellular homeostasis; and photoreceptor cell axon guidance. Part of Dbf4-dependent protein kinase complex and H3 histone acetyltransferase complex. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; germline cell; head epidermis primordium; and somatic cell of testis. Orthologous to several human genes including DBF4 (DBF4-CDC7 kinase regulatory subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 35F1-35F12; 2-52 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (16342430..16352628, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (16342430..16352628, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Drosophila Dbf4 ortholog Chiffon forms a complex with Gcn5 that is necessary for histone acetylation and viability.
Title: The Drosophila Dbf4 ortholog Chiffon forms a complex with Gcn5 that is necessary for histone acetylation and viability.
Cdc7 has a role in endoreplication independent of Chiffon in Drosophila
Title: Characterization of a Drosophila ortholog of the Cdc7 kinase: a role for Cdc7 in endoreplication independent of Chiffon.
Data suggest a model in which ACE3 and ori-beta nucleate the formation of a ORC2-containing chromatin structure that spreads along the chromosome in a mechanism dependent upon chiffon.
Title: Sequence requirements for function of the Drosophila chorion gene locus ACE3 replicator and ori-beta origin elements.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0386 (e-PCR)
- UniSTS:11426

Homology

NCBI Orthologs

Orthologs from OrthoDB

transcript and protein products are distinct from overlapping gene

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chorion-containing eggshell formation	HMP more info	PubMed
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in eggshell chorion gene amplification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nuclear cell cycle DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle phase transition	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Dbf4-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Dbf4-dependent protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of H3 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: chiffon

Names: CG5813-PA; CG5813-PB; CG5813-PD; CG5813-PE; chif-PA; chif-PB; chif-PD; chif-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

16342430..16352628 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078859.4 → NP_523583.2 chiffon, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523583.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8MRI8, Q95S82, Q9NK53, Q9NK54, Q9U9R4, Q9U9R5, Q9VJL0, Q9VJL1

Related

FBpp0080396

Conserved Domains (2) summary

smart00586
Location:307 → 355

ZnF_DBF; Zinc finger in DBF-like proteins

COG5067
Location:40 → 350

DBF4; Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, and repair / Cell division and chromosome partitioning]
NM_001382183.1 → NP_001369130.1 chiffon, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6H2EHD1
NM_165156.3 → NP_723965.1 chiffon, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723965.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PD16

Related

FBpp0080397

Conserved Domains (2) summary

smart00586
Location:307 → 355

ZnF_DBF; Zinc finger in DBF-like proteins

COG5067
Location:40 → 350

DBF4; Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, and repair / Cell division and chromosome partitioning]
NM_001273570.2 → NP_001260499.1 chiffon, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260499.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PD16

Conserved Domains (2) summary

smart00586
Location:307 → 355

ZnF_DBF; Zinc finger in DBF-like proteins

COG5067
Location:40 → 350

DBF4; Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, and repair / Cell division and chromosome partitioning]