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CaBP1 calcium-binding protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34976, updated on 9-Dec-2024

Summary

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Official Symbol
CaBP1provided by FlyBase
Official Full Name
calcium-binding protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0025678
Locus tag
Dmel_CG5809
See related
AllianceGenome:FB:FBgn0025678
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAL28897; BG:DS09218.4; CaBp1; CG5809; DmCaBP1; Dmel\CG5809
Summary
Predicted to enable protein-disulfide reductase activity. Involved in positive regulation of apoptotic cell clearance. Located in endoplasmic reticulum. Is expressed in several structures, including adult heart; embryonic anal pad; embryonic dorsal epidermis; gut section; and head. Orthologous to human PDIA6 (protein disulfide isomerase family A member 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CaBP1 in Genome Data Viewer
Location:
35F12-35F12; 2-52 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16354886..16356735, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16354886..16356735, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Hyls1 centriolar and ciliogenesis associated Neighboring gene chiffon Neighboring gene uncharacterized protein Neighboring gene juvenile hormone acid methyltransferase Neighboring gene uncharacterized protein Neighboring gene Imaginal disc growth factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A homologue of the calcium-binding disulfide isomerase CaBP1 is expressed in the developing CNS of Drosophila melanogaster. Li Y, et al. Dev Genet, 1998. PMID 9770267
  2. Apoptosis-dependent externalization and involvement in apoptotic cell clearance of DmCaBP1, an endoplasmic reticulum protein of Drosophila. Okada R, et al. J Biol Chem, 2012 Jan 27. PMID 22158613, Free PMC Article
  3. Protection of Insects against Viral Infection by Apoptosis-Dependent Phagocytosis. Nainu F, et al. J Immunol, 2015 Dec 15. PMID 26546607
  4. The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder. Williams MJ, et al. PLoS Genet, 2016 Jun. PMID 27280443, Free PMC Article
  5. The thioredoxin-like fold: hidden domains in protein disulfide isomerases and other chaperone proteins. Clissold PM, et al. Bioessays, 2003 Jun. PMID 12766950

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Apoptosis-dependent externalization and involvement in apoptotic cell clearance of DmCaBP1, an endoplasmic reticulum protein of Drosophila.
    Title: Apoptosis-dependent externalization and involvement in apoptotic cell clearance of DmCaBP1, an endoplasmic reticulum protein of Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein disulfide isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of apoptotic cell clearance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calcium-binding protein 1
Names
CG5809-PA
CG5809-PB
CaBP1-PA
CaBP1-PB
NP_001285979.1
NP_609792.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16354886..16356735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299050.1 → NP_001285979.1  calcium-binding protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285979.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V438
    Conserved Domains (3) summary
    cd02983
    Location:271 → 400
    P5_C; P5 family, C-terminal redox inactive TRX-like domain; P5 is a protein disulfide isomerase (PDI)-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is ...
    cd03001
    Location:157 → 262
    PDI_a_P5; PDIa family, P5 subfamily; composed of eukaryotic proteins similar to human P5, a PDI-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is located in the ...
    pfam13848
    Location:190 → 383
    Thioredoxin_6; Thioredoxin-like domain

  2. NM_135948.4 → NP_609792.1  calcium-binding protein 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609792.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V438
    Related
    FBpp0080395
    Conserved Domains (3) summary
    cd02983
    Location:271 → 400
    P5_C; P5 family, C-terminal redox inactive TRX-like domain; P5 is a protein disulfide isomerase (PDI)-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is ...
    cd03001
    Location:157 → 262
    PDI_a_P5; PDIa family, P5 subfamily; composed of eukaryotic proteins similar to human P5, a PDI-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is located in the ...
    pfam13848
    Location:190 → 383
    Thioredoxin_6; Thioredoxin-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V438.1 Q9V438

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