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jhamt juvenile hormone acid methyltransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34977, updated on 9-Dec-2024

Summary

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Official Symbol
jhamtprovided by FlyBase
Official Full Name
juvenile hormone acid methyltransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0028841
Locus tag
Dmel_CG17330
See related
AllianceGenome:FB:FBgn0028841
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS09218.5; CG17330; Dmel\CG17330; DmJHAMT; JAHMT; Jhamt; JHamt; JHAMT
Summary
Enables farnesoic acid O-methyltransferase activity. Involved in juvenile hormone biosynthetic process and male courtship behavior. Predicted to be active in mitochondrion. Is expressed in several structures, including corpus allatum; embryonic somatic muscle cell; larval brain; and ring gland. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See jhamt in Genome Data Viewer
Location:
35F12-35F12; 2-52 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16365903..16367039)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16365903..16367039)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene calcium-binding protein 1 Neighboring gene uncharacterized protein Neighboring gene Imaginal disc growth factor 1 Neighboring gene Imaginal disc growth factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence for differential biosynthesis of juvenile hormone (and related) sesquiterpenoids in Drosophila melanogaster. Bendena WG, et al. Gen Comp Endocrinol, 2011 May 15. PMID 21354154
  2. Juvenile Hormone Is Required in Adult Males for Drosophila Courtship. Wijesekera TP, et al. PLoS One, 2016. PMID 27003411, Free PMC Article
  3. Production of FAME biodiesel in E. coli by direct methylation with an insect enzyme. Sherkhanov S, et al. Sci Rep, 2016 Apr 7. PMID 27053100, Free PMC Article
  4. Photosynthetic production of biodiesel in Synechocystis sp. PCC6803 transformed with insect or plant fatty acid methyltransferase. Kang MJ, et al. Bioprocess Biosyst Eng, 2021 Jul. PMID 33656615
  5. Juvenile hormone synthesis: "esterify then epoxidize" or "epoxidize then esterify"? Insights from the structural characterization of juvenile hormone acid methyltransferase. Defelipe LA, et al. Insect Biochem Mol Biol, 2011 Apr. PMID 21195763, Free PMC Article

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of function of the miRNA bantam in the fly Drosophila melanogaster increased JHAMT expression, while overexpression of the bantam repressed JHAMT expression and resulted in pupal lethality. In addition, there was a conserved set of miRNAs that interacted with JHAMT, and the sesquiterpenoid receptor methoprene-tolerant (Met).
    Title: MicroRNAs regulate the sesquiterpenoid hormonal pathway in Drosophila and other arthropods.
  2. Data show that juvenile hormone acid O-methyltransferase (DmJHAMT) methylates a broad spectrum of fatty acids.
    Title: Production of FAME biodiesel in E. coli by direct methylation with an insect enzyme.
  3. conclude that glutamate promotes dpp expression in corpus allatum, which stimulates juvenile hormone biosynthesis through Tkv and Mad by upregulating JH acid methyltransferase transcription at early larval stages to prevent premature metamorphosis
    Title: DPP-mediated TGFbeta signaling regulates juvenile hormone biosynthesis by activating the expression of juvenile hormone acid methyltransferase.
  4. JHAMT is predominantly expressed in corpora allata, and its developmental expression profile correlates with changes in the juvenile hormone titer.
    Title: Juvenile hormone acid O-methyltransferase in Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables farnesoic acid O-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in juvenile hormone biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in juvenile hormone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male courtship behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
juvenile hormone acid methyltransferase
Names
CG17330-PA
CG17330-PB
jhamt-PA
jhamt-PB
juvenile hormone acid O-Methyl transferase
juvenile hormone acid O-Methyltransferase
juvenile hormone acid methyl transferase
NP_001285980.1
NP_609793.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16365903..16367039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299051.1 → NP_001285980.1  juvenile hormone acid methyltransferase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285980.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q767F0, Q8T900, Q9VJK8
    Conserved Domains (2) summary
    COG0500
    Location:6 → 230
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam08242
    Location:40 → 137
    Methyltransf_12; Methyltransferase domain

  2. NM_135949.3 → NP_609793.2  juvenile hormone acid methyltransferase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609793.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q767F0, Q8T900, Q9VJK8
    Related
    FBpp0099678
    Conserved Domains (2) summary
    COG0500
    Location:6 → 230
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam08242
    Location:40 → 137
    Methyltransf_12; Methyltransferase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJK8.2 Q9VJK8

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