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Idgf1 Imaginal disc growth factor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34978, updated on 9-Dec-2024

Summary

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Official Symbol
Idgf1provided by FlyBase
Official Full Name
Imaginal disc growth factor 1provided by FlyBase
Primary source
FLYBASE:FBgn0020416
Locus tag
Dmel_CG4472
See related
AllianceGenome:FB:FBgn0020416
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS02780.5; CG4472; Dmel\CG4472; DmIDGF1; IDGF; IDGF-1; idgf1; IDGF1; ldgf1
Summary
Enables imaginal disc growth factor receptor binding activity. Involved in several processes, including chitin-based cuticle development; ecdysis, chitin-based cuticle; and epithelium regeneration. Predicted to be active in extracellular region. Is expressed in several structures, including adult head; amnioproctodeal invagination; epithelial furrow; female germline cell; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIT1 (chitinase 1); CHI3L1 (chitinase 3 like 1); and CHI3L2 (chitinase 3 like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Idgf1 in Genome Data Viewer
Location:
36A1-36A1; 2-52 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16445278..16446793)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16445278..16446793)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene calcium-binding protein 1 Neighboring gene juvenile hormone acid methyltransferase Neighboring gene uncharacterized protein Neighboring gene Imaginal disc growth factor 2 Neighboring gene Imaginal disc growth factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CO2 exposure drives a rapid pH response in live adult Drosophila. Zimmerman SG, et al. PLoS One, 2024. PMID 38625910, Free PMC Article
  2. Dis3L2 regulates cell proliferation and tissue growth through a conserved mechanism. Towler BP, et al. PLoS Genet, 2020 Dec. PMID 33370287, Free PMC Article
  3. Crystal structure of imaginal disc growth factor-2. A member of a new family of growth-promoting glycoproteins from Drosophila melanogaster. Varela PF, et al. J Biol Chem, 2002 Apr 12. PMID 11821393
  4. Proteomics Analysis Identifies Orthologs of Human Chitinase-Like Proteins as Inducers of Tube Morphogenesis Defects in Drosophila melanogaster. Zimmerman SG, et al. Genetics, 2017 Jun. PMID 28404605, Free PMC Article
  5. Expansion of Imaginal Disc Growth Factor Gene Family in Diptera Reflects the Evolution of Novel Functions. Zurovcova M, et al. Insects, 2019 Oct 20. PMID 31635152, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
enables imaginal disc growth factor receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin-based cuticle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ecdysis, chitin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelium regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of stem cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
imaginal disc growth factor 1
Names
CG4472-PA
Idgf1-PA
imaginal disc growth factor1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16445278..16446793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057910.5 → NP_477258.1  imaginal disc growth factor 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477258.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O96664, Q8MM24, Q8MM30, Q8MM31, Q8MM38, Q8MM92, Q8MX42, Q8MX43, Q8MX44, Q8MX45, Q8MX46, Q8MX47, Q8MX48, Q8MX49, Q8MX50, Q9V3P8
    Related
    FBpp0080417
    Conserved Domains (2) summary
    cd02873
    Location:23 → 438
    GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
    smart00636
    Location:24 → 417
    Glyco_18; Glyco_18 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MM24.2 Q8MM24

Gene LinkOut

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