Idgf2 Imaginal disc growth factor 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Idgf2provided by FlyBase
Official Full Name: Imaginal disc growth factor 2provided by FlyBase
Primary source: FLYBASE:FBgn0020415
Locus tag: Dmel_CG4475
See related: AllianceGenome:FB:FBgn0020415
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BG:DS02780.4; CG4475; Dmel\CG4475; DmIDGF2; IDGF; IDGF-2; idgf2; IDGF2; ldgf2
Summary: Enables imaginal disc growth factor receptor binding activity. Involved in imaginal disc development; negative regulation of apoptotic process; and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including adult head; epithelial furrow; female germline cell; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIT1 (chitinase 1); CHI3L1 (chitinase 3 like 1); and CHI3L2 (chitinase 3 like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 36A1-36A1; 2-52 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (16447330..16450508)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (16447330..16450508)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results indicate that Idgf2 and Idgf3 might be involved in different yet crucial immune functions in the Drosophila anti-nematode immune response. Idgf2 and Idgf3 modulate distinct immune functions in Drosophila larvae in response to Steinernema nematode infection.
Title: The Imaginal Disc Growth Factors 2 and 3 participate in the Drosophila response to nematode infection.
These findings provide evidence that IDGF2 is an important trophic factor promoting cellular and organismal survival.
Title: Drosophila imaginal disc growth factor 2 is a trophic factor involved in energy balance, detoxification, and innate immunity.
ifferential mass spectrometry analysis of these cells detected elevated levels of four of the six Idgf family members (Idgf1, Idgf2, Idgf4, and Idgf6) in flies mutant for bullwinkle (bwk), which encodes a transcription factor and is a known regulator of DA-tube morphogenesis. We show that, during oogenesis, dysregulation of Idgfs (either gain or loss of function) disrupts the formation of the DA tubes
Title: Proteomics Analysis Identifies Orthologs of Human Chitinase-Like Proteins as Inducers of Tube Morphogenesis Defects in Drosophila melanogaster.
determination of cystal structure
Title: Crystal structure of imaginal disc growth factor-2. A member of a new family of growth-promoting glycoproteins from Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chitin binding	IEA Inferred from Electronic Annotation more info
enables imaginal disc growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chitin catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in imaginal disc development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: imaginal disc growth factor 2

Names: CG4475-PA; CG4475-PB; CG4475-PC; Idgf2-PA; Idgf2-PB; Idgf2-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

16447330..16450508

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259114.2 → NP_001246043.1 imaginal disc growth factor 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246043.1

Status: REVIEWED

UniProtKB/TrEMBL

D4G7B1

Conserved Domains (2) summary

cd02873
Location:1 → 368

GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...

smart00636
Location:2 → 347

Glyco_18; Glyco_18 domain
NM_057909.5 → NP_477257.2 imaginal disc growth factor 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477257.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O96665, Q9V3D4

Related

FBpp0080418

Conserved Domains (1) summary

cd02873
Location:23 → 440

GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
NM_001259113.2 → NP_001246042.1 imaginal disc growth factor 2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246042.1

Status: REVIEWED

UniProtKB/TrEMBL

D4G7B1

Conserved Domains (2) summary

cd02873
Location:1 → 368

GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...

smart00636
Location:2 → 347

Glyco_18; Glyco_18 domain