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Tpr2 Tetratricopeptide repeat protein 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34984, updated on 9-Dec-2024

Summary

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Official Symbol
Tpr2provided by FlyBase
Official Full Name
Tetratricopeptide repeat protein 2provided by FlyBase
Primary source
FLYBASE:FBgn0032586
Locus tag
Dmel_CG4599
See related
AllianceGenome:FB:FBgn0032586
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:LD24941; CG4599; Dmel\CG4599; dtpr2; dTpr2; dTPR2; dtrpr2; EU3220; Tpr-2; tpr2; TPR2; Trp2
Summary
Predicted to enable heat shock protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be located in cytosol and nucleoplasm. Is expressed in adult head. Orthologous to human DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Tpr2 in Genome Data Viewer
Location:
36A2-36A2; 2-52 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16491540..16507621)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16491540..16507621)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44994 Neighboring gene Neprilysin-like 8 Neighboring gene uncharacterized protein Neighboring gene mir-4943 stem loop Neighboring gene long non-coding RNA:CR45354

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic suppression of polyglutamine toxicity in Drosophila. Kazemi-Esfarjani P, et al. Science, 2000 Mar 10. PMID 10710314
  2. Beyond the Qs in the polyglutamine diseases. Orr HT. Genes Dev, 2001 Apr 15. PMID 11316786
  3. Identification of protein quality control regulators using a Drosophila model of TPI deficiency. Hrizo SL, et al. Neurobiol Dis, 2021 May. PMID 33600953, Free PMC Article
  4. AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease. Liévens JC, et al. Hum Mol Genet, 2008 Mar 15. PMID 18065778
  5. Comparison of pathways controlling toxicity in the eye and brain in Drosophila models of human neurodegenerative diseases. Ghosh S, et al. Hum Mol Genet, 2004 Sep 15. PMID 15254017

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heat shock protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 2
Names
CG4599-PA
CG4599-PB
CG4599-PC
CG4599-PD
CG4599-PE
Tpr2-PA
Tpr2-PB
Tpr2-PC
Tpr2-PD
Tpr2-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16491540..16507621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273572.1 → NP_001260501.1  tetratricopeptide repeat protein 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260501.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGL2, Q9V3W1
    Conserved Domains (5) summary
    COG0484
    Location:401 → 503
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:310 → 344
    TPR; TPR repeat [structural motif]
    pfam00226
    Location:402 → 469
    DnaJ; DnaJ domain
    pfam00515
    Location:231 → 264
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:49 → 114
    TPR_11; TPR repeat

  2. NM_001273573.1 → NP_001260502.1  tetratricopeptide repeat protein 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260502.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGL2, Q8IP18
    Conserved Domains (5) summary
    COG0484
    Location:357 → 459
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:266 → 300
    TPR; TPR repeat [structural motif]
    pfam00226
    Location:358 → 425
    DnaJ; DnaJ domain
    pfam00515
    Location:187 → 220
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:5 → 70
    TPR_11; TPR repeat

  3. NM_078860.3 → NP_523584.1  tetratricopeptide repeat protein 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523584.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGL2, Q9V3W1
    Related
    FBpp0080423
    Conserved Domains (5) summary
    COG0484
    Location:401 → 503
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:310 → 344
    TPR; TPR repeat [structural motif]
    pfam00226
    Location:402 → 469
    DnaJ; DnaJ domain
    pfam00515
    Location:231 → 264
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:49 → 114
    TPR_11; TPR repeat

  4. NM_165164.2 → NP_723974.1  tetratricopeptide repeat protein 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723974.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGL2, Q8IP18
    Related
    FBpp0080424
    Conserved Domains (5) summary
    COG0484
    Location:357 → 459
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:266 → 300
    TPR; TPR repeat [structural motif]
    pfam00226
    Location:358 → 425
    DnaJ; DnaJ domain
    pfam00515
    Location:187 → 220
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:5 → 70
    TPR_11; TPR repeat

  5. NM_001273571.1 → NP_001260500.1  tetratricopeptide repeat protein 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260500.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDJ9, Q8IGL2
    Conserved Domains (5) summary
    COG0484
    Location:371 → 473
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:280 → 314
    TPR; TPR repeat [structural motif]
    pfam00226
    Location:372 → 439
    DnaJ; DnaJ domain
    pfam00515
    Location:201 → 234
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:19 → 84
    TPR_11; TPR repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PDJ9 M9PDJ9
Q8IGL2 Q8IGL2
Q8IP18 Q8IP18
Q9V3W1 Q9V3W1

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