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Trpgamma Transient receptor potential cation channel gamma [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34991, updated on 9-Dec-2024

Summary

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Official Symbol
Trpgammaprovided by FlyBase
Official Full Name
Transient receptor potential cation channel gammaprovided by FlyBase
Primary source
FLYBASE:FBgn0032593
Locus tag
Dmel_CG5996
See related
AllianceGenome:FB:FBgn0032593
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5996; Dmel\CG5996; DmTRPgamma; dTRPg; dTRPgamma; trp-gamma; Trp-gamma; trpgamma; TRPgamma
Summary
Enables mechanosensitive monoatomic ion channel activity and monoatomic cation channel activity. Involved in adult walking behavior; monoatomic cation transport; and neuromuscular process controlling posture. Located in neuronal cell body; proximal dendrite; and rhabdomere. Part of cation channel complex. Is expressed in femoral chordotonal organ and spermatozoon. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to several human genes including TRPC4 (transient receptor potential cation channel subfamily C member 4) and TRPC5 (transient receptor potential cation channel subfamily C member 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Trpgamma in Genome Data Viewer
Location:
36A9-36A10; 2-52 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16663454..16676701, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16663454..16676701, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene miles to go Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44151 Neighboring gene mir-2497 stem loop Neighboring gene hermaphrodite Neighboring gene squash Neighboring gene grapes

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in trpγ, the homologue of TRPC6 autism candidate gene, causes autism-like behavioral deficits in Drosophila. Palacios-Muñoz A, et al. Mol Psychiatry, 2022 Aug. PMID 35501408, Free PMC Article
  2. TRPgamma channels are inhibited by cAMP and contribute to pacemaking in neurosecretory insect neurons. Wicher D, et al. J Biol Chem, 2006 Feb 10. PMID 16319060
  3. Molecular basis for the sensitivity of TRP channels to polyunsaturated fatty acids. Riehle M, et al. Naunyn Schmiedebergs Arch Pharmacol, 2018 Aug. PMID 29736621, Free PMC Article
  4. Receptor-induced activation of Drosophila TRP gamma by polyunsaturated fatty acids. Jörs S, et al. J Biol Chem, 2006 Oct 6. PMID 16901908
  5. Drosophila females receive male substrate-borne signals through specific leg neurons during courtship. McKelvey EGZ, et al. Curr Biol, 2021 Sep 13. PMID 34174209, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c16665715-16665658 mobile_element_type = transposon:INE-1{}3317

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mechanosensitive monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adult walking behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in detection of light stimulus involved in visual perception ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in monoatomic cation transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuromuscular process controlling posture IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to light stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in response to light stimulus TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cation channel complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in proximal dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in rhabdomere IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transient receptor potential cation channel gamma
Names
CG5996-PA
CG5996-PB
CG5996-PD
Trpgamma-PA
Trpgamma-PB
Trpgamma-PD
trpgamma
NP_001137830.2
  • non-AUG (CUG) translation initiation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16663454..16676701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144358.3 → NP_001137830.2  transient receptor potential cation channel gamma, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137830.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZW4
    Conserved Domains (5) summary
    cd00204
    Location:113 → 217
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:77 → 841
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:227 → 286
    TRP_2; Transient receptor ion channel II
    pfam17075
    Location:778 → 892
    RRT14; Regular of rDNA transcription protein 14
    sd00045
    Location:118 → 147
    ANK; ANK repeat [structural motif]

  2. NM_165169.5 → NP_723983.1  transient receptor potential cation channel gamma, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723983.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0S8, Q9N6L1, Q9VJJ7
    Related
    FBpp0080499
    Conserved Domains (5) summary
    cd00204
    Location:52 → 156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:16 → 780
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:166 → 225
    TRP_2; Transient receptor ion channel II
    pfam17075
    Location:717 → 832
    RRT14; Regular of rDNA transcription protein 14
    sd00045
    Location:57 → 86
    ANK; ANK repeat [structural motif]

  3. NM_135958.5 → NP_609802.1  transient receptor potential cation channel gamma, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609802.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V0S8, Q9N6L1, Q9VJJ7
    Related
    FBpp0080498
    Conserved Domains (5) summary
    cd00204
    Location:52 → 156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    TIGR00870
    Location:16 → 780
    trp; transient-receptor-potential calcium channel protein
    pfam08344
    Location:166 → 225
    TRP_2; Transient receptor ion channel II
    pfam17075
    Location:717 → 832
    RRT14; Regular of rDNA transcription protein 14
    sd00045
    Location:57 → 86
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7YZW4 B7YZW4
Q9VJJ7.2 Q9VJJ7

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