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her hermaphrodite [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34992, updated on 9-Dec-2024

Summary

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Official Symbol
herprovided by FlyBase
Official Full Name
hermaphroditeprovided by FlyBase
Primary source
FLYBASE:FBgn0001185
Locus tag
Dmel_CG4694
See related
AllianceGenome:FB:FBgn0001185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4694; Dmel\CG4694; FBgn 1185; l(2)mat
Summary
Predicted to enable DNA binding activity. Involved in sex determination. Is expressed in embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See her in Genome Data Viewer
Location:
36A10-36A10; 2-52 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16677185..16679691)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16677185..16679691)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene miles to go Neighboring gene long non-coding RNA:CR44151 Neighboring gene Transient receptor potential cation channel gamma Neighboring gene mir-2497 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene squash Neighboring gene grapes

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Maternal Inheritance of a Sex-Limited Lethal Effect in DROSOPHILA MELANOGASTER. Redfield H. Genetics, 1926 Sep. PMID 17246468, Free PMC Article
  2. A genetic analysis of hermaphrodite, a pleiotropic sex determination gene in Drosophila melanogaster. Pultz MA, et al. Genetics, 1994 Jan. PMID 8138157, Free PMC Article
  3. Sex determination and dosage compensation in Drosophila melanogaster. Baker BS, et al. Annu Rev Genet, 1983. PMID 6421227
  4. hermaphrodite and doublesex function both dependently and independently to control various aspects of sexual differentiation in Drosophila. Li H, et al. Development, 1998 Jul. PMID 9636079
  5. The dual role of hermaphrodite in the Drosophila sex determination regulatory hierarchy. Pultz MA, et al. Development, 1995 Jan. PMID 7867511

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in female somatic sex determination NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in sex determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sex determination, primary response to X:A ratio TAS
Traceable Author Statement
more info
 PubMed 
involved_in sex differentiation TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
hermaphrodite
Names
CG4694-PA
CG4694-PB
her-PA
her-PB
lethal (2) maternal
lethal(2)maternal

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16677185..16679691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273577.1 → NP_001260506.1  hermaphrodite, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260506.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61373, Q9VJJ6
    Conserved Domains (3) summary
    PRK09510
    Location:140 → 220
    tolA; cell envelope integrity inner membrane protein TolA; Provisional
    sd00017
    Location:23 → 45
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132 → 149
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_057224.5 → NP_476572.1  hermaphrodite, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476572.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61373, Q9VJJ6
    Related
    FBpp0080440
    Conserved Domains (3) summary
    PRK09510
    Location:140 → 220
    tolA; cell envelope integrity inner membrane protein TolA; Provisional
    sd00017
    Location:23 → 45
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:132 → 149
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O61373 O61373
Q9VJJ6 Q9VJJ6

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