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qua quail [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35058, updated on 4-Jan-2025

Summary

Official Symbol
quaprovided by FlyBase
Official Full Name
quailprovided by FlyBase
Primary source
FLYBASE:FBgn0003187
Locus tag
Dmel_CG6433
See related
AllianceGenome:FB:FBgn0003187
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.71; CG6433; Dmel\CG6433; fs(2)A12; Qua
Summary
Enables actin binding activity. Involved in imaginal disc-derived wing hair organization. Located in cytoplasm. Colocalizes with actin filament. Is expressed in several structures, including border follicle cell; dorsal epidermis primordium; germline cell; gonad; and gut section. Human ortholog(s) of this gene implicated in Finnish type amyloidosis and nephrotic syndrome type 21. Orthologous to several human genes including AVIL (advillin); CAPG (capping actin protein, gelsolin like); and GSN (gelsolin). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See qua in Genome Data Viewer
Location:
36C10-36C10; 2-53 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17486806..17497208, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17486806..17497208, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45715 Neighboring gene uncharacterized protein Neighboring gene mitochondrial translation elongation factor Ts

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in imaginal disc-derived wing hair organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ovarian nurse cell to oocyte transport HMP PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with actin filament IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
quail
Names
CG6433-PA
CG6433-PB
CG6433-PC
female sterile(2)A12
qua-PA
qua-PB
qua-PC
villin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    17486806..17497208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165222.2NP_724060.1  quail, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724060.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23989
    Related
    FBpp0080549
    Conserved Domains (5) summary
    smart00153
    Location:852887
    VHP; Villin headpiece domain
    cd11280
    Location:684775
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:271370
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    smart00262
    Location:419521
    GEL; Gelsolin homology domain
    cl15697
    Location:25152
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  2. NM_165223.3NP_724061.1  quail, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724061.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23989, Q540V4, Q8INY7, Q9VJC9
    UniProtKB/TrEMBL
    D0IQH1
    Related
    FBpp0080550
    Conserved Domains (5) summary
    smart00153
    Location:853888
    VHP; Villin headpiece domain
    cd11280
    Location:685776
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:272371
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    smart00262
    Location:420522
    GEL; Gelsolin homology domain
    cl15697
    Location:26153
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  3. NM_001259137.2NP_001246066.1  quail, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246066.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NF69
    Conserved Domains (5) summary
    smart00153
    Location:857892
    VHP; Villin headpiece domain
    cd11280
    Location:689780
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:276375
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    smart00262
    Location:424526
    GEL; Gelsolin homology domain
    cl15697
    Location:26147
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains