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mEFTs mitochondrial translation elongation factor Ts [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35060, updated on 9-Dec-2024

Summary

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Official Symbol
mEFTsprovided by FlyBase
Official Full Name
mitochondrial translation elongation factor Tsprovided by FlyBase
Primary source
FLYBASE:FBgn0032646
Locus tag
Dmel_CG6412
See related
AllianceGenome:FB:FBgn0032646
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6412; Dmel\CG6412; mtEF-Ts
Summary
Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation and regulation of mitochondrial translation. Predicted to be located in mitochondrion. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic large intestine; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 3. Orthologous to human TSFM (Ts translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See mEFTs in Genome Data Viewer
Location:
36C10-36C10; 2-53 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17499268..17501106, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17499268..17501106, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene quail Neighboring gene antisense RNA:CR45715 Neighboring gene uncharacterized protein Neighboring gene Dynein heavy chain at 36C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Paradoxical Mitophagy Regulation by PINK1 and TUFm. Lin J, et al. Mol Cell, 2020 Nov 19. PMID 33113344
  2. Energy biogenesis: one key for coordinating two genomes. Sardiello M, et al. Trends Genet, 2005 Jan. PMID 15680507
  3. Deficiency of ValRS-m Causes Male Infertility in Drosophila melanogaster. Duan X, et al. Int J Mol Sci, 2024 Jul 8. PMID 39000597, Free PMC Article
  4. Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model. Park JE, et al. Exp Mol Med, 2023 Jul. PMID 37464094, Free PMC Article
  5. Extensive use of RNA-binding proteins in Drosophila sensory neuron dendrite morphogenesis. Olesnicky EC, et al. G3 (Bethesda), 2014 Feb 19. PMID 24347626, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
mitochondrial translation elongation factor Ts
Names
CG6412-PA
mEFTs-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    17499268..17501106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136003.5 → NP_609847.1  mitochondrial translation elongation factor Ts [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609847.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VJC7
    Related
    FBpp0080547
    Conserved Domains (3) summary
    COG0264
    Location:35 → 303
    Tsf; Translation elongation factor EF-Ts [Translation, ribosomal structure and biogenesis]
    cd14275
    Location:32 → 66
    UBA_EF-Ts; UBA domain found in elongation factor Ts (EF-Ts) from bacteria, chloroplasts and mitochondria of eukaryotes
    pfam00889
    Location:98 → 300
    EF_TS; Elongation factor TS
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJC7.1 Q9VJC7

Gene LinkOut

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