Dhc36C Dynein heavy chain at 36C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dhc36Cprovided by FlyBase
Official Full Name: Dynein heavy chain at 36Cprovided by FlyBase
Primary source: FLYBASE:FBgn0013810
Locus tag: Dmel_CG5526
See related: AllianceGenome:FB:FBgn0013810
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5526; dhc; Dhc; DHC; Dhc 36C; Dhc36c; DHC7A; Dmel\CG5526
Summary: Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in flagellated sperm motility and sensory perception of sound. Is active in sperm flagellum. Is expressed in adult head; chordotonal neurons; spermatogonium; spermatozoon; and testis. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human DNAH7 (dynein axonemal heavy chain 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (17501401..17525515)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (17501401..17525515)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables minus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables minus-end-directed microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables minus-end-directed microtubule motor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cilium movement involved in cell motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in flagellated sperm motility	IEP Inferred from Expression Pattern more info	PubMed
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in 9+2 motile cilium	IBA Inferred from Biological aspect of Ancestor more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
part_of inner dynein arm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed

Names: CG5526-PB; CG5526-PC; Dhc36C-PB; Dhc36C-PC; dynein-related heavy chain polypeptide

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