U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

btv beethoven [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35073, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
btvprovided by FlyBase
Official Full Name
beethovenprovided by FlyBase
Primary source
FLYBASE:FBgn0023096
Locus tag
Dmel_CG15148
See related
AllianceGenome:FB:FBgn0023096
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15148; DHC; DHC2; Dhc36D; DHC36D; Dmel\CG15148
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in several processes, including adult walking behavior; intraciliary retrograde transport; and male courtship behavior, veined wing generated song production. Located in axoneme. Is expressed in chordotonal organ precursor cell; external sensory organ precursor cell; and spermatozoon. Used to study nonsyndromic deafness. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy and asphyxiating thoracic dystrophy 3. Orthologous to human DYNC2H1 (dynein cytoplasmic 2 heavy chain 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See btv in Genome Data Viewer
Location:
36E3-36E3; 2-53 cM
Exon count:
25
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17962625..17982472, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17962625..17982472, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44399 Neighboring gene long non-coding RNA:CR44398 Neighboring gene long non-coding RNA:CR44397 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Proteasome beta5 subunit-related 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A Mismatch EndoNuclease Array-Based Methodology (MENA) for Identifying Known SNPs or Novel Point Mutations. Comeron JM, et al. Microarrays (Basel), 2016 Apr 5. PMID 27600073, Free PMC Article
  2. Power gain exhibited by motile mechanosensory neurons in Drosophila ears. Göpfert MC, et al. Proc Natl Acad Sci U S A, 2005 Jan 11. PMID 15623551, Free PMC Article
  3. Song production in auditory mutants of Drosophila: the role of sensory feedback. Tauber E, et al. J Comp Physiol A, 2001 Jun. PMID 11529478
  4. More whistles and bells for fly hearing. Walker RG. Proc Natl Acad Sci U S A, 2003 May 13. PMID 12732710, Free PMC Article
  5. Motion generation by Drosophila mechanosensory neurons. Göpfert MC, et al. Proc Natl Acad Sci U S A, 2003 Apr 29. PMID 12642657, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables minus-end-directed microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables minus-end-directed microtubule motor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in adult walking behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in auditory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary retrograde transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary retrograde transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male courtship behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male courtship behavior, veined wing generated song production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in 9+2 motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
beethoven
Names
CG15148-PD
DyneinHC
btv-PD
dynein heavy chain 36D

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    17962625..17982472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042904.4 → NP_001036369.3  beethoven [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036369.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8P6
    Conserved Domains (6) summary
    pfam03028
    Location:3536 → 4051
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:200 → 618
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1072 → 1481
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:2821 → 3138
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:3179 → 3401
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:1621 → 1847
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0E8P6 Q0E8P6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools