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Socs36E Suppressor of cytokine signaling at 36E [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35085, updated on 9-Dec-2024

Summary

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Official Symbol
Socs36Eprovided by FlyBase
Official Full Name
Suppressor of cytokine signaling at 36Eprovided by FlyBase
Primary source
FLYBASE:FBgn0041184
Locus tag
Dmel_CG15154
See related
AllianceGenome:FB:FBgn0041184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Liang-2.2; CG15154; clone 2.2; Dmel\CG15154; dmSocs36E; dSOCS; SCOS36E; Socs; SOCS; Socs36; SOCS36; socs36e; socs36E; Socs36e; SocS36E; SOCS36E; socs60E1
Summary
Enables cytokine receptor binding activity and sevenless binding activity. Involved in several processes, including border follicle cell migration; negative regulation of signal transduction; and wing disc morphogenesis. Is expressed in several structures, including cardiogenic mesoderm; follicle cell; gut section; mesoderm; and muscle cell. Orthologous to several human genes including SOCS4 (suppressor of cytokine signaling 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Socs36E in Genome Data Viewer
Location:
36E6-36E6; 2-53 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18138675..18152417, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18138675..18152417, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor-like 36b Neighboring gene kelch Neighboring gene long non-coding RNA:CR44478 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic screen of chemotherapeutics in Drosophila stem cell tumors. Markstein M, et al. Proc Natl Acad Sci U S A, 2014 Mar 25. PMID 24616500, Free PMC Article
  2. Effects of unpaired 1 gene overexpression on the lifespan of Drosophila melanogaster. Moskalev A, et al. BMC Syst Biol, 2019 Mar 5. PMID 30836998, Free PMC Article
  3. Competition between SOCS36E and Drk modulates Sevenless receptor tyrosine kinase activity. Almudi I, et al. J Cell Sci, 2010 Nov 15. PMID 20980384
  4. Cloning and expression of Drosophila SOCS36E and its potential regulation by the JAK/STAT pathway. Karsten P, et al. Mech Dev, 2002 Sep. PMID 12204282
  5. GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. Bach EA, et al. Gene Expr Patterns, 2007 Jan. PMID 17008134

See all (226) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. contributes mechanistic insight to a Jak/STAT regulatory genetic circuit, and suggests that Socs36E regulates Jak/STAT signaling via a Cul2-dependent mechanism, as well as by a Cullin-independent manner, in vivo
    Title: Socs36E limits STAT signaling via Cullin2 and a SOCS-box independent mechanism in the Drosophila egg chamber.
  2. Socs36E is node through which these processes are linked, demonstrating that negative feedback inhibition integrates multiple aspects of stem cell behavior.
    Title: Socs36E Controls Niche Competition by Repressing MAPK Signaling in the Drosophila Testis.
  3. The Drosophila JAK/STAT pathway regulator SOCS36E functions via two independent mechanisms.
    Title: Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms.
  4. Socs36E attenuates STAT signaling to optimize motile cell specification in the Drosophila ovary.
    Title: Socs36E attenuates STAT signaling to optimize motile cell specification in the Drosophila ovary.
  5. study found the JAK-STAT signaling target & inhibitor, SOCS36E, is required for germline stem cell maintenance; SOCS36E suppresses JAK-STAT signaling specifically in the somatic stem cells, preventing them from displacing neighboring germline stem cells
    Title: JAK-STAT signal inhibition regulates competition in the Drosophila testis stem cell niche.
  6. Socs36E constitutes a novel partially redundant feedback mechanism that contributes to the robustness of R7 specification. The SOCS family of adaptor proteins may have evolved as modulators of specific signaling pathways.
    Title: SOCS36E specifically interferes with Sevenless signaling during Drosophila eye development.
  7. cloning and expression pattern during embryonic and imaginal disc development
    Title: Cloning and expression of Drosophila SOCS36E and its potential regulation by the JAK/STAT pathway.
  8. SOCS36E suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc
    Title: SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cytokine receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sevenless binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell dedifferentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in compound eye pigmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in haltere development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing vein morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of R7 cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of R7 cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of receptor signaling pathway via JAK-STAT IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of sevenless signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of sevenless signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in notum morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lysosomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
suppressor of cytokine signaling at 36E
Names
CG15154-PA
CG15154-PC
CG15154-PD
Socs36E-PA
Socs36E-PC
Socs36E-PD
suppressor of cytokine signaling
suppressor of cytokine signaling 36E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    18138675..18152417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273605.2 → NP_001260534.1  suppressor of cytokine signaling at 36E, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260534.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P82, Q8WTC3, Q9VJA1
    Conserved Domains (2) summary
    cl02533
    Location:575 → 626
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    cl15255
    Location:463 → 563
    SH2; Src homology 2 (SH2) domain

  2. NM_165243.3 → NP_724096.1  suppressor of cytokine signaling at 36E, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724096.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P82, Q8WTC3, Q9VJA1
    Related
    FBpp0080593
    Conserved Domains (2) summary
    cl02533
    Location:575 → 626
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    cl15255
    Location:463 → 563
    SH2; Src homology 2 (SH2) domain

  3. NM_078869.6 → NP_523593.5  suppressor of cytokine signaling at 36E, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523593.5

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P82, Q8INY1
    Conserved Domains (2) summary
    cl02533
    Location:575 → 626
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    cl15255
    Location:463 → 563
    SH2; Src homology 2 (SH2) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86P82 Q86P82
Q8INY1 Q8INY1
Q8WTC2 Q8WTC2
Q9VJA1 Q9VJA1

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