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grnd grindelwald [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35103, updated on 9-Dec-2024

Summary

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Official Symbol
grndprovided by FlyBase
Official Full Name
grindelwaldprovided by FlyBase
Primary source
FLYBASE:FBgn0032682
Locus tag
Dmel_CG10176
See related
AllianceGenome:FB:FBgn0032682
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10176; Dmel\CG10176; Grnd
Summary
Enables tumor necrosis factor receptor activity. Involved in positive regulation of JNK cascade and tumor necrosis factor-mediated signaling pathway. Is active in plasma membrane. Is expressed in several structures, including anlage in statu nascendi; clypeo-labral anlage; clypeo-labral primordium; dorsal ectoderm; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See grnd in Genome Data Viewer
Location:
36F5-36F5; 2-53 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18485417..18488021)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18485417..18488021)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene let-7 Complex Neighboring gene mir-125 stem loop Neighboring gene uncharacterized protein Neighboring gene kon-tiki Neighboring gene UDP-glycosyltransferase family 301 member D1 Neighboring gene long non-coding RNA:CR44903 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reactive oxygen species activate the Drosophila TNF receptor Wengen for damage-induced regeneration. Esteban-Collado J, et al. EMBO J, 2024 Sep. PMID 39020149, Free PMC Article
  2. Upregulated TNF/Eiger signaling mediates stem cell recovery and tissue homeostasis during nutrient resupply in Drosophila testis. Chang YC, et al. Sci Rep, 2020 Jul 15. PMID 32669615, Free PMC Article
  3. A novel injury paradigm in the central nervous system of adult Drosophila: molecular, cellular and functional aspects. Losada-Pérez M, et al. Dis Model Mech, 2021 May 1. PMID 34061177, Free PMC Article
  4. Gene Set Enrichment Analysis and Genetic Experiment Reveal Changes in Cell Signaling Pathways Induced by α-Synuclein Overexpression. Huang Y, et al. Biomedicines, 2023 Jan 18. PMID 36830800, Free PMC Article
  5. Drosophila TNF Modulates Tissue Tension in the Embryo to Facilitate Macrophage Invasive Migration. Ratheesh A, et al. Dev Cell, 2018 May 7. PMID 29738712

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
    Title: Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables tumor necrosis factor receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of negative regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of positive regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of positive regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
grindelwald
Names
CG10176-PB
CG10176-PC
grnd-PB
grnd-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    18485417..18488021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273609.1 → NP_001260538.1  grindelwald, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260538.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SXT4, Q9VJ83

  2. NM_136036.4 → NP_609880.2  grindelwald, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609880.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SXT4, Q9VJ83
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJ83.2 Q9VJ83

Gene LinkOut

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