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CG10383 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35123, updated on 9-Dec-2024

Summary

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Official Symbol
CG10383provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032699
Locus tag
Dmel_CG10383
See related
AllianceGenome:FB:FBgn0032699
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10383
Summary
Involved in determination of adult lifespan. Is expressed in adult head. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome. Orthologous to human SERAC1 (serine active site containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG10383 in Genome Data Viewer
Location:
37A1-37A1; 2-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18690904..18695602, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18690904..18695602, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tosca Neighboring gene male-specific lethal 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Consistent effects of a major QTL for thermal resistance in field-released Drosophila melanogaster. Loeschcke V, et al. J Insect Physiol, 2011 Sep. PMID 21708160
  2. Genome-wide characterization of chromatin binding and nucleosome spacing activity of the nucleosome remodelling ATPase ISWI. Sala A, et al. EMBO J, 2011 May 4. PMID 21448136, Free PMC Article
  3. Combined expression patterns of QTL-linked candidate genes best predict thermotolerance in Drosophila melanogaster. Norry FM, et al. J Insect Physiol, 2009 Nov. PMID 19651134
  4. The effect of a synergistic concentration of a Piper nigrum extract used in conjunction with pyrethrum upon gene expression in Drosophila melanogaster. Jensen HR, et al. Insect Mol Biol, 2006 Jun. PMID 16756552
  5. Genome-wide identification of neuronal activity-regulated genes in Drosophila. Chen X, et al. Elife, 2016 Dec 9. PMID 27936378, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10383-PA
CG10383-PB
NP_001286055.1
NP_609896.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    18690904..18695602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299126.1 → NP_001286055.1  uncharacterized protein Dmel_CG10383, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286055.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJ64
    Conserved Domains (1) summary
    cl21494
    Location:522 → 642
    Abhydrolase; alpha/beta hydrolases

  2. NM_136052.3 → NP_609896.1  uncharacterized protein Dmel_CG10383, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609896.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJ64
    Related
    FBpp0088571
    Conserved Domains (1) summary
    cl21494
    Location:522 → 642
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q961H4 Q961H4
Q9VJ64 Q9VJ64

Gene LinkOut

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