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tup tailup [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35147, updated on 9-Dec-2024

Summary

Official Symbol
tupprovided by FlyBase
Official Full Name
tailupprovided by FlyBase
Primary source
FLYBASE:FBgn0003896
Locus tag
Dmel_CG10619
See related
AllianceGenome:FB:FBgn0003896
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10619; Dmel\CG10619; isl; Isl; islet; Islet; l(2)37Aa; l(2)E41; Tailup; Tup; TUP
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; neuron projection guidance; and notum cell fate specification. Located in nucleus. Is expressed in several structures, including adult uniglomerular antennal lobe projection neurons; cardial cell; ganglia; lineage NB3-1 primary motor neurons; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in atrial fibrillation; congenital heart disease (multiple); diabetes mellitus (multiple); dilated cardiomyopathy; and myocardial infarction. Orthologous to human ISL1 (ISL LIM homeobox 1) and ISL2 (ISL LIM homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See tup in Genome Data Viewer
Location:
37B1-37B1; 2-54 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18859507..18881261, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18859507..18881261, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L13 Neighboring gene mir-4946 stem loop Neighboring gene long non-coding RNA:CR44737 Neighboring gene long non-coding RNA:CR44739

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in amnioserosa maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chaeta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chaeta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germ-band shortening IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in head involution NAS
Non-traceable Author Statement
more info
PubMed 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymph gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in muscle cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron fate specification IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron fate specification IEA
Inferred from Electronic Annotation
more info
 
involved_in notum cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tailup
Names
CG10619-PA
CG10619-PB
CG10619-PC
dIslet
islet
islet 1
lethal(2)37Aa
tail-up
tailup/islet
tup-PA
tup-PB
tup-PC

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    18859507..18881261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057427.3NP_476775.1  tailup, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476775.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P92031, Q9VJ37
    Related
    FBpp0080661
    Conserved Domains (3) summary
    cd09366
    Location:54108
    LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family
    cd09374
    Location:116171
    LIM2_Isl; The second LIM domain of Isl, a member of LHX protein family
    smart00389
    Location:241297
    HOX; Homeodomain
  2. NM_057426.4NP_476774.1  tailup, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476774.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P92031, Q9Y0Z9
    Related
    FBpp0080662
    Conserved Domains (3) summary
    cd09366
    Location:54108
    LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family
    cd09374
    Location:116171
    LIM2_Isl; The second LIM domain of Isl, a member of LHX protein family
    smart00389
    Location:241297
    HOX; Homeodomain
  3. NM_001299139.1NP_001286068.1  tailup, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286068.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P92031, Q9VJ37
    Conserved Domains (3) summary
    cd09366
    Location:54108
    LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family
    cd09374
    Location:116171
    LIM2_Isl; The second LIM domain of Isl, a member of LHX protein family
    smart00389
    Location:241297
    HOX; Homeodomain