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tup - tailup

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; neuron projection guidance; and notum cell fate specification. Located in nucleus. Is expressed in several structures, including adult uniglomerular antennal lobe projection neurons; dorsal vessel wall cell; ganglia; lineage NB3-1 primary motor neurons; and segmentally-repeated neuroblast. Human ortholog(s) of this gene implicated in atrial fibrillation; congenital heart disease (multiple); diabetes mellitus (multiple); dilated cardiomyopathy; and myocardial infarction. Orthologous to human ISL1 (ISL LIM homeobox 1) and ISL2 (ISL LIM homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]

Genes similar to tup

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Species Gene Architecture aa