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ssp3 short spindle 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35149, updated on 9-Dec-2024

Summary

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Official Symbol
ssp3provided by FlyBase
Official Full Name
short spindle 3provided by FlyBase
Primary source
FLYBASE:FBgn0032723
Locus tag
Dmel_CG18397
See related
AllianceGenome:FB:FBgn0032723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10666; CG18397; Dmel\CG18397; Ssp3
Summary
Located in spindle. Is expressed in adult head. Used to study Bardet-Biedl syndrome and azoospermia. Orthologous to human SCAPER (S-phase cyclin A associated protein in the ER). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See ssp3 in Genome Data Viewer
Location:
37B5-37B6; 2-54 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18916347..18943960, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18916347..18943960, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44739 Neighboring gene long non-coding RNA:CR44738 Neighboring gene long non-coding RNA:CR44740 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Absence of SCAPER causes male infertility in humans and Drosophila by modulating microtubule dynamics during meiosis. Wormser O, et al. J Med Genet, 2021 Apr. PMID 32527956, Free PMC Article
  2. GWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise. Watanabe LP, et al. Sci Rep, 2021 Mar 4. PMID 33664357, Free PMC Article
  3. Identification of downstream targets of the bone morphogenetic protein pathway in the Drosophila nervous system. Kim NC, et al. Dev Dyn, 2010 Sep. PMID 20652954
  4. Chromatin immunoprecipitation reveals a novel role for the Drosophila SoxNeuro transcription factor in axonal patterning. Girard F, et al. Dev Biol, 2006 Nov 15. PMID 16979619
  5. Male-specific fruitless isoforms target neurodevelopmental genes to specify a sexually dimorphic nervous system. Neville MC, et al. Curr Biol, 2014 Feb 3. PMID 24440396, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Absence of SCAPER causes male infertility in humans and Drosophila by modulating microtubule dynamics during meiosis.
    Title: Absence of SCAPER causes male infertility in humans and Drosophila by modulating microtubule dynamics during meiosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
short spindle 3
Names
CG18397-PA
CG18397-PB
ssp3-PA
ssp3-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    18916347..18943960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299140.1 → NP_001286069.1  short spindle 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286069.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J6U8
    Conserved Domains (4) summary
    pfam15665
    Location:868 → 1058
    FAM184; Family with sequence similarity 184, A and B
    pfam16501
    Location:111 → 206
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cl02488
    Location:989 → 1190
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl20817
    Location:1109 → 1191
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. NM_136073.3 → NP_609917.2  short spindle 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609917.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJ35, Q9VJ36
    Related
    FBpp0080734
    Conserved Domains (4) summary
    pfam15665
    Location:870 → 1060
    FAM184; Family with sequence similarity 184, A and B
    pfam16501
    Location:113 → 208
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
    cl02488
    Location:991 → 1192
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl20817
    Location:1111 → 1193
    GBP_C; Guanylate-binding protein, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJ35 Q9VJ35
X2J6U8 X2J6U8

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