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Sidpn similar to Deadpan [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35168, updated on 9-Dec-2024

Summary

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Official Symbol
Sidpnprovided by FlyBase
Official Full Name
similar to Deadpanprovided by FlyBase
Primary source
FLYBASE:FBgn0032741
Locus tag
Dmel_CG10446
See related
AllianceGenome:FB:FBgn0032741
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bHLHe51; CG10446; Dmel\CG10446; side; Side
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; eye; ganglia; larval nervous system; and spermatozoon. Orthologous to several human genes including BHLHE40 (basic helix-loop-helix family member e40); BHLHE41 (basic helix-loop-helix family member e41); and HES3 (hes family bHLH transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Sidpn in Genome Data Viewer
Location:
37B9-37B10; 2-54 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19027710..19030780)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19027710..19030780)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43700 Neighboring gene uncharacterized protein Neighboring gene hook Neighboring gene uncharacterized protein Neighboring gene mind bomb 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Maternal Groucho and bHLH repressors amplify the dose-sensitive X chromosome signal in Drosophila sex determination. Lu H, et al. Dev Biol, 2008 Nov 15. PMID 18773886, Free PMC Article
  2. The MTE, a new core promoter element for transcription by RNA polymerase II. Lim CY, et al. Genes Dev, 2004 Jul 1. PMID 15231738, Free PMC Article
  3. A genomewide survey of basic helix-loop-helix factors in Drosophila. Moore AW, et al. Proc Natl Acad Sci U S A, 2000 Sep 12. PMID 10973473, Free PMC Article
  4. Dynamics of Gene Co-expression Networks in Time-Series Data: A Case Study in Drosophila melanogaster Embryogenesis. Lau LY, et al. Front Genet, 2020. PMID 32528531, Free PMC Article
  5. The two Tribolium E(spl) genes show evolutionarily conserved expression and function during embryonic neurogenesis. Kux K, et al. Mech Dev, 2013 Apr-May. PMID 23485410

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Beat-Sidestep interaction network provides insights into Drosophila neuromuscular system development.
    Title: Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
NP_523599.1
  • similar to deadpan

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19027710..19030780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078875.3 → NP_523599.1  uncharacterized protein Dmel_CG10446 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523599.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJ16
    Related
    FBpp0080685
    Conserved Domains (2) summary
    cd00083
    Location:48 → 117
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam07527
    Location:125 → 172
    Hairy_orange; Hairy Orange
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJ16 Q9VJ16

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