U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ttc19 Tetratricopeptide repeat domain 19 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35172, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Ttc19provided by FlyBase
Official Full Name
Tetratricopeptide repeat domain 19provided by FlyBase
Primary source
FLYBASE:FBgn0032744
Locus tag
Dmel_CG15173
See related
AllianceGenome:FB:FBgn0032744
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg15173; CG15173; Dmel\CG15173; dTTC19; TTC19
Summary
Involved in jump response; mitochondrial respiratory chain complex III assembly; and optomotor response. Located in mitochondrion. Is expressed in adult head; embryonic/larval midgut; and organism. Used to study mitochondrial complex III deficiency nuclear type 2. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 2. Orthologous to human TTC19 (tetratricopeptide repeat domain 19). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ttc19 in Genome Data Viewer
Location:
37B11-37B11; 2-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19043535..19045148, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19043535..19045148, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene hook Neighboring gene uncharacterized protein Neighboring gene mind bomb 2 Neighboring gene Catecholamines up Neighboring gene Acinus Neighboring gene uncharacterized protein Neighboring gene lethal (2) 37Bb

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction. Peruzzo R, et al. Nat Commun, 2021 Apr 8. PMID 33833234, Free PMC Article
  2. Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies. Ghezzi D, et al. Nat Genet, 2011 Mar. PMID 21278747
  3. Mitochondrial diseases: Drosophila melanogaster as a model to evaluate potential therapeutics. Foriel S, et al. Int J Biochem Cell Biol, 2015 Jun. PMID 25666557
  4. Mitochondrial Neurodegeneration: Lessons from Drosophila melanogaster Models. Brischigliaro M, et al. Biomolecules, 2023 Feb 16. PMID 36830747, Free PMC Article
  5. Transcriptomic and proteomic profiling of glial versus neuronal Dube3a overexpression reveals common molecular changes in gliopathic epilepsies. Hope KA, et al. Neurobiol Dis, 2020 Jul. PMID 32344153, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in jump response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial respiratory chain complex III assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex III assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex III assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in optomotor response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
tetratricopeptide repeat domain 19
Names
CG15173-PA
Ttc19-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19043535..19045148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136090.3 → NP_609934.3  tetratricopeptide repeat domain 19 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609934.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SYD0, Q9VJ13
    Related
    FBpp0080720
    Conserved Domains (3) summary
    sd00006
    Location:269 → 299
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:272 → 339
    TPR_11; TPR repeat
    pfam13424
    Location:235 → 302
    TPR_12; Tetratricopeptide repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SYD0.1 Q8SYD0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools