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Ddc Dopa decarboxylase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35190, updated on 12-Dec-2024

Summary

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Official Symbol
Ddcprovided by FlyBase
Official Full Name
Dopa decarboxylaseprovided by FlyBase
Primary source
FLYBASE:FBgn0000422
Locus tag
Dmel_CG10697
See related
AllianceGenome:FB:FBgn0000422
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AADC; CG10697; ddc; DDC; DdcDm; Dmel\CG10697; fDDC; l(2)37Bl; l(2)37Ch; l(2)k02104
Summary
Enables 5-hydroxy-L-tryptophan decarboxylase activity and L-dopa decarboxylase activity. Involved in several processes, including adult chitin-containing cuticle pigmentation; aromatic amino acid metabolic process; and memory. Predicted to be active in cytoplasm. Is expressed in several structures, including aminergic neurons; epithelium; ganglia; gut section; and mushroom body medial lobe. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; inherited metabolic disorder; and nicotine dependence. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ddc in Genome Data Viewer
Location:
37C1-37C1; 2-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19116483..19120306, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19116483..19120306, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44905 Neighboring gene alpha methyl dopa-resistant Neighboring gene uncharacterized protein Neighboring gene Prohibitin 1 Neighboring gene lethal (2) 37Cb

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The metabolism of tyrosine-O-phosphate in Drosophila. Lunan KD, et al. Arch Biochem Biophys, 1969 Jul. PMID 5797334
  2. Mutations within the Ddc promoter alter its neuron-specific pattern of expression. Scholnick SB, et al. Dev Biol, 1991 Aug. PMID 1864464
  3. Cell-Free Synthesis of Dopamine and Serotonin in Two Steps with Purified Enzymes. Groaz A, et al. Adv Biosyst, 2020 Nov. PMID 33107224
  4. Serotonin synthesis and distribution in Drosophila dopa decarboxylase genetic mosaics. Vallés AM, et al. J Neurosci, 1990 Nov. PMID 2230952, Free PMC Article
  5. Regulation of dopa decarboxylase gene expression in the larval epidermis of the tobacco hornworm by 20-hydroxyecdysone and juvenile hormone. Hiruma K, et al. Dev Biol, 1990 Mar. PMID 2407577

See all (389) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. lowered expression of Atg6 or Pi3K59F in Ddc-Gal4-expressing neurons results in decreased longevity and associated age-dependent loss of locomotor ability. Inhibition of Atg6 or Pi3K59F together with overexpression of the sole pro-survival Bcl-2 Drosophila homolog Buffy in Ddc-Gal4-expressing neurons resulted in further decrease in the survival
    Title: Inhibition of Atg6 and Pi3K59F autophagy genes in neurons decreases lifespan and locomotor ability in Drosophila melanogaster.
  2. The involvement of DDC in a new pathway involved in Drosophila immunity increases the levels of dopamine, which is metabolized to produce reactive quinones that exert an antimicrobial effect on invading bacteria.
    Title: A member of the p38 mitogen-activated protein kinase family is responsible for transcriptional induction of Dopa decarboxylase in the epidermis of Drosophila melanogaster during the innate immune response.
  3. The Ddc locus exhibits a complicated pattern of variation apparently due to several evolutionary forces.
    Title: Nucleotide variation at the dopa decarboxylase (Ddc) gene in natural populations of Drosophila melanogaster.
  4. evidence for a wound response pathway that senses aseptic breaks in the barrier epidermis of Drosophila embryos; a minimal 472-bp Ddc wound response enhancer requires a Grh protein binding site and the function of the grh gene
    Title: An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head.
  5. epidermal Ddc induction at pupariation is under the control of an extended genomic region that contains both positive and negative regulatory elements
    Title: Induction of the early-late Ddc gene during Drosophila metamorphosis by the ecdysone receptor.
  6. Broad-Complex protein is required for Ddc activation at eclosion in Drosophila
    Title: Control of Dopa decarboxylase gene expression by the Broad-Complex during metamorphosis in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 5-hydroxy-L-tryptophan decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-dopa decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aromatic-L-amino-acid decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aromatic-L-amino-acid decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aromatic-L-amino-acid decarboxylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adult chitin-containing cuticle pigmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in anesthesia-resistant memory IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in catecholamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dopamine biosynthetic process from tyrosine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-term memory IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of adult chitin-containing cuticle pigmentation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of adult chitin-containing cuticle pigmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to wounding IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in serotonin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in serotonin biosynthetic process from tryptophan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in thermosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in thermotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dopa decarboxylase
Names
3,4-Dihydroxyphenylalanine decarboxylase
CG10697-PB
CG10697-PC
CG10697-PD
Ddc-PB
Ddc-PC
Ddc-PD
L-3,4-dihydroxyphenylalanine decarboxylase
L-dopa decarboxylase
aromatic L-amino acid decarboxylase
aromatic amino acid decarboxylase
dopa-decarboxylase
dopadecarboxylase
dopamine decarboxylase
transcription unit No. 3
NP_523600.5
NP_724163.1
NP_724164.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19116483..19120306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165280.2 → NP_724164.1  dopa decarboxylase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724164.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F0JAJ7
    Related
    FBpp0080709
    Conserved Domains (1) summary
    pfam00282
    Location:35 → 411
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

  2. NM_165279.2 → NP_724163.1  dopa decarboxylase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724163.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18379, P05031, P05032, Q24295, Q7YSJ0, Q7YSK5, Q7YSV6, Q7Z0E1, Q7Z0E2, Q7Z0E3, Q7Z0E4, Q7Z0E5, Q7Z0E6, Q7Z0E7, Q7Z0E8, Q7Z0E9, Q95SL9, Q9VIZ5, Q9VIZ6
    UniProtKB/TrEMBL
    F0JAJ6
    Related
    FBpp0080710
    Conserved Domains (1) summary
    pfam00282
    Location:70 → 446
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

  3. NM_078876.5 → NP_523600.5  dopa decarboxylase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523600.5

    Status: REVIEWED

    UniProtKB/TrEMBL
    F0JAJ7
    Conserved Domains (1) summary
    pfam00282
    Location:35 → 411
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05031.4 P05031

Gene LinkOut

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