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RanGAP Ran GTPase activating protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35223, updated on 9-Dec-2024

Summary

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Official Symbol
RanGAPprovided by FlyBase
Official Full Name
Ran GTPase activating proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0003346
Locus tag
Dmel_CG9999
See related
AllianceGenome:FB:FBgn0003346
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9999; CT28175; Dmel\CG9999; dmRanGAP; dRanGAP; Ran; rangap; ranGap; ranGAP; Rangap; RanGap; RanGap1; RanGAP1; RGP1_DROME; Scl; Sd; SD; Sd-RanGap; Sd-RanGAP
Summary
Enables GTPase activator activity and RNA binding activity. Involved in protein export from nucleus and regulation of nucleocytoplasmic transport. Located in perinuclear region of cytoplasm. Is expressed in several structures, including CNS glial cell; anlage in statu nascendi; endoderm anlage; head epidermis primordium; and mesoderm. Orthologous to human RANGAP1 (Ran GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See RanGAP in Genome Data Viewer
Location:
37E1-37E1; 2-54 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19441959..19447317)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19441959..19447317)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene RtcB RNA ligase Neighboring gene Rab9 Neighboring gene uncharacterized protein Neighboring gene Heparan sulfate 2-O-sulfotransferase Neighboring gene Topoisomerase 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selfish genes and meiotic drive. Hurst LD. Nature, 1998 Jan 15. PMID 9440681
  2. The Y Chromosome as a Battleground for Intragenomic Conflict. Bachtrog D. Trends Genet, 2020 Jul. PMID 32448494, Free PMC Article
  3. Dynamics of spermiogenesis in Drosophila melanogaster. I. Individualization process. Tokuyasu KT, et al. Z Zellforsch Mikrosk Anat, 1972. PMID 4622067
  4. Dynamics of spermiogenesis in Drosophila melanogaster. II. Coiling process. Tokuyasu KT, et al. Z Zellforsch Mikrosk Anat, 1972. PMID 4625686
  5. Aging effect on the phenomenon of segregation distortion in Drosophila melanogaster. Hiraizumi Y, et al. Genetics, 1969 Sep. PMID 5365286, Free PMC Article

See all (182) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sexual selection can partly explain low frequencies of Segregation Distorter alleles.
    Title: Sexual selection can partly explain low frequencies of Segregation Distorter alleles.
  2. A cross-eyed geneticist's view VI. Segregation distortion in Drosophila melanogaster: Recent progress in solving 'an esoteric puzzle'.
    Title: A cross-eyed geneticist's view VI. Segregation distortion in Drosophila melanogaster: Recent progress in solving 'an esoteric puzzle'.
  3. Fitness consequences of the selfish supergene Segregation Distorter.
    Title: Fitness consequences of the selfish supergene Segregation Distorter.
  4. in larval brain neuroblasts, an intrinsic mechanism facilitates import and export of Pros across the nuclear envelope via a Ran-mediated nucleocytoplasmic transport system.
    Title: RanGAP-mediated nucleocytoplasmic transport of Prospero regulates neural stem cell lifespan in Drosophila larval central brain.
  5. molecular and evolutionary genetics of Segregation Distorter
    Title: The selfish Segregation Distorter gene complex of Drosophila melanogaster.
  6. Sd, the primary gene responsible for segregation distortion, encodes a mutant RanGAP, a key protein in the Ran signaling pathway required for nuclear transport and other nuclear functions.
    Title: Closing the (Ran)GAP on segregation distortion in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in meiotic chromosome segregation TAS
Traceable Author Statement
more info
 PubMed 
involved_in nuclear export IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleocytoplasmic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of nucleocytoplasmic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ran GTPase activating protein
Names
CG9999-PA
CG9999-PB
CG9999-PC
Ran-GTPase activating protein
RanGAP-PA
RanGAP-PB
RanGAP-PC
segregation distorter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19441959..19447317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057364.4 → NP_476712.1  Ran GTPase activating protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476712.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VIW3, Q9XZI5
    UniProtKB/TrEMBL
    A0A0E3X848, M9PBD9
    Related
    FBpp0080775
    Conserved Domains (2) summary
    cd00116
    Location:50 → 337
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:45 → 77
    LRR_RI; leucine-rich repeat [structural motif]

  2. NM_001273650.1 → NP_001260579.1  Ran GTPase activating protein, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260579.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0E3X848, M9PD65
    Conserved Domains (2) summary
    cd00116
    Location:42 → 329
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:37 → 69
    LRR_RI; leucine-rich repeat [structural motif]

  3. NM_001273649.1 → NP_001260578.1  Ran GTPase activating protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260578.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VIW3, Q9XZI5
    UniProtKB/TrEMBL
    A0A0E3X848, M9PBD9
    Conserved Domains (2) summary
    cd00116
    Location:50 → 337
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:45 → 77
    LRR_RI; leucine-rich repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBD9 M9PBD9
M9PD65 M9PD65
Q9VIW3.1 Q9VIW3

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