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Ctu2 Cytosolic thiouridylase subunit 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35234, updated on 9-Dec-2024

Summary

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Official Symbol
Ctu2provided by FlyBase
Official Full Name
Cytosolic thiouridylase subunit 2provided by FlyBase
Primary source
FLYBASE:FBgn0032793
Locus tag
Dmel_CG10189
See related
AllianceGenome:FB:FBgn0032793
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10189; CTU2; Dmel\CG10189; i180; i199
Summary
Predicted to enable sulfurtransferase activity. Predicted to be involved in tRNA wobble position uridine thiolation. Predicted to be part of cytosolic tRNA wobble base thiouridylase complex. Predicted to be active in cytosol. Orthologous to human CTU2 (cytosolic thiouridylase subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Ctu2 in Genome Data Viewer
Location:
37E4-37E4; 2-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19491647..19493253, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19491647..19493253, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene second mitotic wave missing Neighboring gene Topoisomerase 3alpha Neighboring gene cysts

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants. Planelles-Herrero VJ, et al. Nat Cell Biol, 2022 Nov. PMID 36302967, Free PMC Article
  2. Isolation of proteins that interact with the signal transduction molecule Dof and identification of a functional domain conserved between Dof and vertebrate BCAP. Battersby A, et al. J Mol Biol, 2003 Jun 6. PMID 12767830
  3. Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet. Çiçek IÖ, et al. Genetics, 2016 Mar. PMID 26801178, Free PMC Article
  4. Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. Blanco E, et al. BMC Dev Biol, 2010 Sep 2. PMID 20813047, Free PMC Article
  5. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tRNA thio-modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA thio-modification ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA wobble position uridine thiolation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble uridine modification ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of cytosolic tRNA wobble base thiouridylase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cytosolic thiouridylase subunit 2
Names
CG10189-PA
CG10189-PB
Ctu2-PA
Ctu2-PB
NP_001260585.1
NP_609975.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19491647..19493253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273656.1 → NP_001260585.1  cytosolic thiouridylase subunit 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260585.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5X547, M9PDQ5, Q8MT91, Q9VIV3
    Conserved Domains (1) summary
    pfam10288
    Location:295 → 393
    CTU2; Cytoplasmic tRNA 2-thiolation protein 2

  2. NM_136131.4 → NP_609975.1  cytosolic thiouridylase subunit 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609975.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5X547, M9PDQ5, Q8MT91, Q9VIV3
    Related
    FBpp0080822
    Conserved Domains (1) summary
    pfam10288
    Location:295 → 393
    CTU2; Cytoplasmic tRNA 2-thiolation protein 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VIV3.1 Q9VIV3

Gene LinkOut

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