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Pmvk Phosphomevalonate kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35255, updated on 9-Dec-2024

Summary

Official Symbol
Pmvkprovided by FlyBase
Official Full Name
Phosphomevalonate kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0032811
Locus tag
Dmel_CG10268
See related
AllianceGenome:FB:FBgn0032811
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:SD12705; CG10268; Dmel\CG10268; MevPK; PMVK
Summary
Predicted to enable phosphomevalonate kinase activity. Predicted to be involved in cholesterol biosynthetic process and isopentenyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in peroxisome. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human PMVK (phosphomevalonate kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Pmvk in Genome Data Viewer
Location:
37F2-37F2; 2-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19579093..19580351, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19579093..19580351, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene spitz Neighboring gene mir-2a-1 stem loop Neighboring gene mir-2b-2 stem loop Neighboring gene msb1l Neighboring gene hakai Neighboring gene Proliferating cell nuclear antigen 2

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphomevalonate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphomevalonate kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphomevalonate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in isoprenoid biosynthetic process IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
phosphomevalonate kinase
Names
CG10268-PA
Pmvk-PA
NP_609992.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19579093..19580351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136148.2NP_609992.1  phosphomevalonate kinase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609992.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RJH0, Q8MRY7, Q9VIT2
    Related
    FBpp0080807
    Conserved Domains (1) summary
    TIGR01223
    Location:4188
    Pmev_kin_anim; phosphomevalonate kinase, animal type