Nf-YB Nuclear factor Y-box B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nf-YBprovided by FlyBase
Official Full Name: Nuclear factor Y-box Bprovided by FlyBase
Primary source: FLYBASE:FBgn0032816
Locus tag: Dmel_CG10447
See related: AllianceGenome:FB:FBgn0032816
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RH50436; CG10447; Dmel\CG10447; dNF-YB; NF-YB
Summary: Enables transcription cis-regulatory region binding activity. Contributes to sequence-specific DNA binding activity. Involved in several processes, including positive regulation of DNA-templated transcription; positive regulation of MAPK cascade; and positive regulation of R7 cell differentiation. Part of CCAAT-binding activity factor complex. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Orthologous to human NFYB (nuclear transcription factor Y subunit beta). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (19736044..19737088)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (19736044..19737088)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

dNF-Y regulates debcl gene expression.
Title: dNF-YB plays dual roles in cell death and cell differentiation during Drosophila eye development.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
contributes_to sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of R7 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of CCAAT-binding factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CCAAT-binding factor complex	IDA Inferred from Direct Assay more info	PubMed
part_of CCAAT-binding factor complex	IEA Inferred from Electronic Annotation more info

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