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CdGAPr Cd GTPase activating protein-related [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35267, updated on 9-Dec-2024

Summary

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Official Symbol
CdGAPrprovided by FlyBase
Official Full Name
Cd GTPase activating protein-relatedprovided by FlyBase
Primary source
FLYBASE:FBgn0032821
Locus tag
Dmel_CG10538
See related
AllianceGenome:FB:FBgn0032821
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
10538; cdGAPr; CG10538; d-CdGAPr; Dmel\CG10538; FBgn 32821; GAP
Summary
Predicted to enable GTPase activator activity. Involved in retinal ganglion cell axon guidance. Is expressed in several structures, including embryonic segment posterior compartment; epithelium; organism subdivision; and peripheral sensory precursor cell. Orthologous to several human genes including ARHGAP32 (Rho GTPase activating protein 32). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CdGAPr in Genome Data Viewer
Location:
38A3-38A3; 2-54 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19774874..19791882, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19774874..19791882, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene fructose-1,6-bisphosphatase Neighboring gene brain-specific homeobox Neighboring gene female sterile (2) ltoPP43 Neighboring gene uncharacterized protein Neighboring gene small nuclear RNA U4 at 38AB Neighboring gene sickie

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynamic expression of d-CdGAPr, a novel Drosophila melanogaster gene encoding a GTPase activating protein. Sagnier T, et al. Mech Dev, 2000 Jun. PMID 10842085
  2. Focal adhesion kinase controls morphogenesis of the Drosophila optic stalk. Murakami S, et al. Development, 2007 Apr. PMID 17360775
  3. Inference of RhoGAP/GTPase regulation using single-cell morphological data from a combinatorial RNAi screen. Nir O, et al. Genome Res, 2010 Mar. PMID 20144944, Free PMC Article
  4. Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. Hu H, et al. Proc Natl Acad Sci U S A, 2005 Mar 22. PMID 15755809, Free PMC Article
  5. RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion. Fic W, et al. J Cell Biol, 2021 Apr 5. PMID 33646271, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in retinal ganglion cell axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
Cd GTPase activating protein-related
Names
CG10538-PA
CG10538-PB
CG10538-PC
CG10538-PD
CdGAPr-PA
CdGAPr-PB
CdGAPr-PC
CdGAPr-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19774874..19791882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273671.2 → NP_001260600.1  Cd GTPase activating protein-related, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260600.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6AWI4, Q8MSV9, Q9NCL1, Q9VIS1
    UniProtKB/TrEMBL
    M9PDR8
    Conserved Domains (4) summary
    cd11835
    Location:299 → 358
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:420 → 613
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:168 → 274
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl23733
    Location:1322 → 1457
    FliJ; Flagellar FliJ protein

  2. NM_136158.5 → NP_610002.1  Cd GTPase activating protein-related, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610002.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6AWI4, Q8MSV9, Q9NCL1, Q9VIS1
    UniProtKB/TrEMBL
    M9PDR8
    Related
    FBpp0080851
    Conserved Domains (4) summary
    cd11835
    Location:299 → 358
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:420 → 613
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:168 → 274
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl23733
    Location:1322 → 1457
    FliJ; Flagellar FliJ protein

  3. NM_001169547.2 → NP_001163018.1  Cd GTPase activating protein-related, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163018.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JHM0
    Conserved Domains (4) summary
    cd11835
    Location:299 → 358
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:420 → 613
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:168 → 274
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl23733
    Location:1321 → 1456
    FliJ; Flagellar FliJ protein

  4. NM_001169546.2 → NP_001163017.1  Cd GTPase activating protein-related, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163017.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JHM1
    Conserved Domains (4) summary
    cd11835
    Location:299 → 358
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:420 → 613
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:168 → 274
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl23733
    Location:1321 → 1456
    FliJ; Flagellar FliJ protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JHM0 E1JHM0
E1JHM1 E1JHM1
M9PDR8 M9PDR8
Q9VIS1.2 Q9VIS1

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