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Kua Kua [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35300, updated on 4-Jan-2025

Summary

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Official Symbol
Kuaprovided by FlyBase
Official Full Name
Kuaprovided by FlyBase
Primary source
FLYBASE:FBgn0032850
Locus tag
Dmel_CG10723
See related
AllianceGenome:FB:FBgn0032850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
38B.18; CG10723; Dmel\CG10723
Summary
Predicted to enable plasmanylethanolamine desaturase activity. Predicted to be located in membrane. Is expressed in embryonic antennal sense organ. Orthologous to human PEDS1-UBE2V1 (PEDS1-UBE2V1 readthrough) and PEDS1 (plasmanylethanolamine desaturase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Kua in Genome Data Viewer
Location:
38B6-38C1; 2-54 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20097581..20103375)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20097581..20103375)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene nessun dorma Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new function evolved from gene fusion. Long M. Genome Res, 2000 Nov. PMID 11076848
  2. Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. Thomson TM, et al. Genome Res, 2000 Nov. PMID 11076860, Free PMC Article
  3. Molecular Profiling of the Drosophila Antenna Reveals Conserved Genes Underlying Olfaction in Insects. Mohapatra P, et al. G3 (Bethesda), 2019 Nov 5. PMID 31527046, Free PMC Article
  4. Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain. Mukherjee C, et al. Cell Metab, 2020 Aug 4. PMID 32531201, Free PMC Article
  5. Map position and expression of the genes in the 38 region of Drosophila. Butler H, et al. Genetics, 2001 Aug. PMID 11514449, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

mobile_element

  • Loc: 20099516-20099570 mobile_element_type = transposon:INE-1{}4062

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables plasmanylethanolamine desaturase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
Kua
Names
CG10723-PA
CG10723-PB
CG10723-PC
CG10723-PD
Kua-PA
Kua-PB
Kua-PC
Kua-PD
NP_001188856.1
NP_001260620.1
NP_001260621.1
NP_610026.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    20097581..20103375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273691.1 → NP_001260620.1  Kua, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260620.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3B5
    Conserved Domains (1) summary
    pfam10520
    Location:124 → 301
    TMEM189_B_dmain; B domain of TMEM189, localization domain

  2. NM_001273692.1 → NP_001260621.1  Kua, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260621.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3B5
    Conserved Domains (1) summary
    pfam10520
    Location:124 → 301
    TMEM189_B_dmain; B domain of TMEM189, localization domain

  3. NM_001201927.2 → NP_001188856.1  Kua, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188856.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3B5
    Conserved Domains (1) summary
    pfam10520
    Location:124 → 301
    TMEM189_B_dmain; B domain of TMEM189, localization domain

  4. NM_136182.2 → NP_610026.1  Kua, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610026.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3B5
    Related
    FBpp0080868
    Conserved Domains (1) summary
    pfam10520
    Location:124 → 301
    TMEM189_B_dmain; B domain of TMEM189, localization domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3B5 Q9V3B5

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