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BRCA1 BRCA1 DNA repair associated [ Bos taurus (domestic cattle) ]

Gene ID: 353120, updated on 10-Oct-2024

Summary

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Official Symbol
BRCA1provided by VGNC
Official Full Name
BRCA1 DNA repair associatedprovided by VGNC
Primary source
VGNC:VGNC:55781
See related
BGD:BT11167; Ensembl:ENSBTAG00000022520
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See BRCA1 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (43069050..43140040, complement)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene vesicle amine transport 1 Neighboring gene Rho family GTPase 2 Neighboring gene NBR1 autophagy cargo receptor Neighboring gene transmembrane protein 106A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. BRCA1: a new candidate gene for bovine mastitis and its association analysis between single nucleotide polymorphisms and milk somatic cell score. Yuan Z, et al. Mol Biol Rep, 2012 Jun. PMID 22327776
  2. Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle. Yuan Z, et al. Gene, 2012 Aug 15. PMID 22583824
  3. Reproductive factors and ovarian cancer risk in Jewish BRCA1 and BRCA2 mutation carriers (United States). Modugno F, et al. Cancer Causes Control, 2003 Jun. PMID 12946038
  4. Parallel adaptive radiations in two major clades of placental mammals. Madsen O, et al. Nature, 2001 Feb 1. PMID 11214318
  5. Bovine BRCA1 shows classic responses to genotoxic stress but low in vitro transcriptional activation activity. Krum SA, et al. Oncogene, 2003 Sep 4. PMID 12955082

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle.
    Title: Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle.
  2. The gene-specific SNP marker analysis showed a significant association of BRCA1 C28300A with milk somatic cell scores.
    Title: BRCA1: a new candidate gene for bovine mastitis and its association analysis between single nucleotide polymorphisms and milk somatic cell score.
  3. Bovine BRCA1 was phosphorylated and nuclear speckling was enhanced in response to DNA-damaging agents.These results provide evidence that phosphorylation and nuclear relocalization are highly conserved features of the BRCA1 response to genotoxic stress.
    Title: Bovine BRCA1 shows classic responses to genotoxic stress but low in vitro transcriptional activation activity.
  4. In general, OC use, childbearing and breastfeeding do not differ between BRCA1/2 carriers and non-carriers with ovarian cancer. However, the effects of tubal ligation may differ between BRCA1 carriers and non-carriers.
    Title: Reproductive factors and ovarian cancer risk in Jewish BRCA1 and BRCA2 mutation carriers (United States).
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of BRCA1-BARD1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
breast cancer type 1 susceptibility protein homolog
Names
BRCA1 homologue
RING-type E3 ubiquitin transferase BRCA1
breast and ovarian cancer susceptibility 1
breast cancer 1, early onset
NP_848668.1
XP_005220736.2
XP_010814518.2
XP_059733745.1
XP_059733746.1
XP_059733747.1
XP_059733748.1
XP_059733749.1
XP_059733751.1
XP_059733752.1
XP_059733753.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178573.1 → NP_848668.1  breast cancer type 1 susceptibility protein homolog

    See identical proteins and their annotated locations for NP_848668.1

    Status: PROVISIONAL

    Source sequence(s)
    AY077732
    UniProtKB/Swiss-Prot
    Q864U1
    UniProtKB/TrEMBL
    A0A3Q1MFV5
    Related
    ENSBTAP00000011616.5, ENSBTAT00000011616.5
    Conserved Domains (4) summary
    smart00292
    Location:1752 → 1835
    BRCT; breast cancer carboxy-terminal domain
    cd00027
    Location:1643 → 1717
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd00162
    Location:23 → 68
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam12820
    Location:345 → 505
    BRCT_assoc; Serine-rich domain associated with BRCT

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    43069050..43140040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059877770.1 → XP_059733753.1  breast cancer type 1 susceptibility protein homolog isoform X10

  2. XM_059877764.1 → XP_059733747.1  breast cancer type 1 susceptibility protein homolog isoform X4

  3. XM_059877769.1 → XP_059733752.1  breast cancer type 1 susceptibility protein homolog isoform X9

  4. XM_059877763.1 → XP_059733746.1  breast cancer type 1 susceptibility protein homolog isoform X3

    UniProtKB/TrEMBL
    A0AAA9TSB1
    Related
    ENSBTAP00000101267.1, ENSBTAT00000110697.1

  5. XM_059877768.1 → XP_059733751.1  breast cancer type 1 susceptibility protein homolog isoform X8

    Related
    ENSBTAP00000089820.1, ENSBTAT00000094868.1

  6. XM_059877762.1 → XP_059733745.1  breast cancer type 1 susceptibility protein homolog isoform X2

    UniProtKB/TrEMBL
    A0AAA9SKW6
    Related
    ENSBTAP00000087002.1, ENSBTAT00000129498.1

  7. XM_005220679.5 → XP_005220736.2  breast cancer type 1 susceptibility protein homolog isoform X7

    UniProtKB/TrEMBL
    Q864T9
    Related
    ENSBTAP00000071523.1, ENSBTAT00000071426.2
    Conserved Domains (3) summary
    smart00292
    Location:654 → 737
    BRCT; breast cancer carboxy-terminal domain
    pfam00533
    Location:545 → 618
    BRCT; BRCA1 C Terminus (BRCT) domain
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  8. XM_010816216.4 → XP_010814518.2  breast cancer type 1 susceptibility protein homolog isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MFV5
    Related
    ENSBTAP00000070037.1, ENSBTAT00000082527.2
    Conserved Domains (4) summary
    smart00292
    Location:1752 → 1835
    BRCT; breast cancer carboxy-terminal domain
    pfam00533
    Location:1643 → 1716
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12820
    Location:345 → 505
    BRCT_assoc; Serine-rich domain associated with BRCT
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  9. XM_059877766.1 → XP_059733749.1  breast cancer type 1 susceptibility protein homolog isoform X6

    Related
    ENSBTAP00000067686.2, ENSBTAT00000067174.2

  10. XM_059877765.1 → XP_059733748.1  breast cancer type 1 susceptibility protein homolog isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q864U1.1 GenPept UniProtKB/Swiss-Prot:Q864U1

Gene LinkOut

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Molecular Biology Databases
Research Materials