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CAPG capping actin protein, gelsolin like [ Bos taurus (domestic cattle) ]

Gene ID: 353121, updated on 29-Jan-2025

Summary

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Official Symbol
CAPGprovided by VGNC
Official Full Name
capping actin protein, gelsolin likeprovided by VGNC
Primary source
VGNC:VGNC:26739
See related
BGD:BT17195; Ensembl:ENSBTAG00000005432
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See CAPG in Genome Data Viewer
Location:
chromosome: 11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (49587893..49605835)

Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene methionine adenosyltransferase 2A Neighboring gene SH2 domain containing 6 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene ELMO domain containing 3 Neighboring gene retinol saturase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress. Pellieux C, et al. J Biol Chem, 2003 Aug 1. PMID 12754261
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament severing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in actin polymerization or depolymerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in barbed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell projection assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
macrophage-capping protein
Names
actin regulatory protein CAP-G
capping protein (actin filament), gelsolin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178574.3 → NP_848669.1  macrophage-capping protein

    See identical proteins and their annotated locations for NP_848669.1

    Status: VALIDATED

    Source sequence(s)
    NKLS02000011
    UniProtKB/Swiss-Prot
    Q865V6
    UniProtKB/TrEMBL
    A0AAF7A8X1
    Related
    ENSBTAP00070019852.1, ENSBTAT00070033618.1
    Conserved Domains (3) summary
    cd11289
    Location:138 → 226
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:247 → 347
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    49587893..49605835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024998361.2 → XP_024854129.1  macrophage-capping protein isoform X1

    UniProtKB/Swiss-Prot
    Q865V6
    UniProtKB/TrEMBL
    A0AAF7A8X1
    Conserved Domains (3) summary
    cd11289
    Location:138 → 226
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:247 → 347
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

  2. XM_005212743.4 → XP_005212800.1  macrophage-capping protein isoform X1

    See identical proteins and their annotated locations for XP_005212800.1

    UniProtKB/Swiss-Prot
    Q865V6
    UniProtKB/TrEMBL
    A0AAF7A8X1
    Related
    ENSBTAP00070019836.1, ENSBTAT00070033594.1
    Conserved Domains (3) summary
    cd11289
    Location:138 → 226
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:247 → 347
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

  3. XM_059891029.1 → XP_059747012.1  macrophage-capping protein isoform X1

    UniProtKB/Swiss-Prot
    Q865V6
    UniProtKB/TrEMBL
    A0AAF7A8X1

  4. XM_059891030.1 → XP_059747013.1  macrophage-capping protein isoform X1

    UniProtKB/Swiss-Prot
    Q865V6
    UniProtKB/TrEMBL
    A0AAF7A8X1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q865V6.1 GenPept UniProtKB/Swiss-Prot:Q865V6

Gene LinkOut

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